Repositori URV

Identificador: imarina:5132928

Handle: https://hdl.handle.net/20.500.11797/imarina5132928

Autors:
Reilly, Maureen C.Vohra, SunitaRac, Valeria E.Dunn, MichaelFerrelli, KarlaKiss, AlexVincer, MichaelWimmer, JohnZayack, DeniseSoll, Roger F.Vermont Oxford Network Heat Loss P

Resum:
To determine whether the application of occlusive wrap applied immediately after birth will reduce mortality in very preterm infants.This was a prospective randomized controlled trial of infants born 24 0/7 to 27 6/7 weeks' gestation who were assigned randomly to occlusive wrap or no wrap. The primary outcome was all cause mortality at discharge or 6 months' corrected age. Secondary outcomes included temperature, Apgar scores, pH, base deficit, blood pressure and glucose, respiratory distress syndrome, bronchopulmonary dysplasia, seizures, patent ductus arteriosus, necrotizing enterocolitis, gastrointestinal perforation, intraventricular hemorrhage, cystic periventricular leukomalacia, pulmonary hemorrhage, retinopathy of prematurity, sepsis, hearing screen, and pneumothorax.Eight hundred one infants were enrolled. There was no difference in baseline population characteristics. There were no significant differences in mortality (OR 1.0, 95% CI 0.7-1.5). Wrap infants had statistically significant greater baseline temperatures (36.3°C wrap vs 35.7°C no wrap, P < .0001) and poststabilization temperatures (36.6°C vs 36.2°C, P < .001) than nonwrap infants. For the secondary outcomes, there was a significant decrease in pulmonary hemorrhage (OR 0.6, 95% CI 0.3-0.9) in the wrap group and a significant lower mean one minute Apgar score (P = .007) in the wrap group. The study was stopped early because continued enrollment would not result in the attainment of a significant difference in the primary outcome.Application of occlusive wrap to very preterm infants immediately after birth results in greater mean body temperature but does not reduce mortality.Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.