Autor segons l'article: Ardid-Ruiz, Andrea; Ibars, Maria; Mena, Pedro; Del Rio, Daniele; Muguerza, Begona; Blade, Cinta; Arola, Lluis; Aragones, Gerard; Suarez, Manuel
Departament: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
Autor/s de la URV: Aragonès Bargalló, Gerard / ARDID RUIZ, ANDREA / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel
Paraules clau: Weight gain Stat3 transcription factor Sirtuin Signal transduction Resveratrol Rats, wistar Rats Obesity Microbiota Metabolites Male Leptin resistance Leptin Hypertriglyceridemia Gene expression regulation Dose-response relationship, drug Diet Cafeteria diet Antioxidants Animals Adipose tissue obesity microbiota metabolites leptin resistance cafeteria diet
Resum: Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects. Serum leptin levels and the leptin signaling pathway were assessed in diet-induced obese rats. Moreover, serum metabolites of resveratrol were studied by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MSn). The daily consumption of 200 mg/kg of resveratrol, but not doses of 50 and 100 mg/kg, reduced body weight and fat accumulation in obese rats and restored leptin sensitivity in the periphery. These effects were due to increases in sirtuin 1 activity in the liver, leptin receptors in muscle and protection against endoplasmic reticulum (ER)-stress in adipose tissue. In general, the resveratrol metabolites associated with these beneficial effects were derived from both phase II and microbiota metabolism, although only those derived from microbiota increased proportionally with the administered dose of resveratrol. In conclusion, resveratrol reversed leptin resistance caused by diet-induced obesity in peripheral organs using tissue-specific mechanisms.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Adreça de correu electrònic de l'autor: manuel.suarez@urv.cat gerard.aragones@urv.cat lluis.arola@urv.cat begona.muguerza@urv.cat
Identificador de l'autor: 0000-0003-0122-8253 0000-0003-2767-1974 0000-0001-7384-8588
Data d'alta del registre: 2024-09-07
Volum de revista: 10
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6643/10/11/1757
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nutrients. 10 (11): 1757-
Referència de l'ítem segons les normes APA: Ardid-Ruiz, Andrea; Ibars, Maria; Mena, Pedro; Del Rio, Daniele; Muguerza, Begona; Blade, Cinta; Arola, Lluis; Aragones, Gerard; Suarez, Manuel (2018). Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation. Nutrients, 10(11), 1757-. DOI: 10.3390/nu10111757
DOI de l'article: 10.3390/nu10111757
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications