Articles producció científica> Bioquímica i Biotecnologia

Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation

  • Dades identificatives

    Identificador: imarina:5132944
    Autors:
    Ardid-Ruiz, AndreaIbars, MariaMena, PedroDel Rio, DanieleMuguerza, BegonaBlade, CintaArola, LluisAragones, GerardSuarez, Manuel
    Resum:
    Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects. Serum leptin levels and the leptin signaling pathway were assessed in diet-induced obese rats. Moreover, serum metabolites of resveratrol were studied by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MSn). The daily consumption of 200 mg/kg of resveratrol, but not doses of 50 and 100 mg/kg, reduced body weight and fat accumulation in obese rats and restored leptin sensitivity in the periphery. These effects were due to increases in sirtuin 1 activity in the liver, leptin receptors in muscle and protection against endoplasmic reticulum (ER)-stress in adipose tissue. In general, the resveratrol metabolites associated with these beneficial effects were derived from both phase II and microbiota metabolism, although only those derived from microbiota increased proportionally with the administered dose of resveratrol. In conclusion, resveratrol reversed leptin resistance caused by diet-induced obesity in peripheral organs using tissue-specific mechanisms.
  • Altres:

    Autor segons l'article: Ardid-Ruiz, Andrea; Ibars, Maria; Mena, Pedro; Del Rio, Daniele; Muguerza, Begona; Blade, Cinta; Arola, Lluis; Aragones, Gerard; Suarez, Manuel
    Departament: Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    Autor/s de la URV: Aragonès Bargalló, Gerard / ARDID RUIZ, ANDREA / Arola Ferrer, Luis Maria / BLADÉ SEGARRA, MARIA CINTA / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel
    Paraules clau: Weight gain Stat3 transcription factor Sirtuin Signal transduction Resveratrol Rats, wistar Rats Obesity Microbiota Metabolites Male Leptin resistance Leptin Hypertriglyceridemia Gene expression regulation Dose-response relationship, drug Diet Cafeteria diet Antioxidants Animals Adipose tissue obesity microbiota metabolites leptin resistance cafeteria diet
    Resum: Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects. Serum leptin levels and the leptin signaling pathway were assessed in diet-induced obese rats. Moreover, serum metabolites of resveratrol were studied by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MSn). The daily consumption of 200 mg/kg of resveratrol, but not doses of 50 and 100 mg/kg, reduced body weight and fat accumulation in obese rats and restored leptin sensitivity in the periphery. These effects were due to increases in sirtuin 1 activity in the liver, leptin receptors in muscle and protection against endoplasmic reticulum (ER)-stress in adipose tissue. In general, the resveratrol metabolites associated with these beneficial effects were derived from both phase II and microbiota metabolism, although only those derived from microbiota increased proportionally with the administered dose of resveratrol. In conclusion, resveratrol reversed leptin resistance caused by diet-induced obesity in peripheral organs using tissue-specific mechanisms.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Adreça de correu electrònic de l'autor: manuel.suarez@urv.cat gerard.aragones@urv.cat lluis.arola@urv.cat begona.muguerza@urv.cat
    Identificador de l'autor: 0000-0003-0122-8253 0000-0003-2767-1974 0000-0001-7384-8588
    Data d'alta del registre: 2024-09-07
    Volum de revista: 10
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2072-6643/10/11/1757
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Nutrients. 10 (11): 1757-
    Referència de l'ítem segons les normes APA: Ardid-Ruiz, Andrea; Ibars, Maria; Mena, Pedro; Del Rio, Daniele; Muguerza, Begona; Blade, Cinta; Arola, Lluis; Aragones, Gerard; Suarez, Manuel (2018). Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation. Nutrients, 10(11), 1757-. DOI: 10.3390/nu10111757
    DOI de l'article: 10.3390/nu10111757
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Weight gain
    Stat3 transcription factor
    Sirtuin
    Signal transduction
    Resveratrol
    Rats, wistar
    Rats
    Obesity
    Microbiota
    Metabolites
    Male
    Leptin resistance
    Leptin
    Hypertriglyceridemia
    Gene expression regulation
    Dose-response relationship, drug
    Diet
    Cafeteria diet
    Antioxidants
    Animals
    Adipose tissue
    obesity
    microbiota
    metabolites
    leptin resistance
    cafeteria diet
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar