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Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

  • Dades identificatives

    Identificador: imarina:5132993
    Autors:
    Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG
    Resum:
    The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read-across. Currently, lacking toxicokinetic data often prevent the application of read-across. Preferably, toxicokinetic data should be generated using in vitro and in silico tools and anchored towards human relevance. In certain sectors, PBK modelling is being used for risk assessment, but less so in others. Specific activities were identified to facilitate the use of in vitro and in silico toxicokinetic data to support read-across: The collation of available tools indicating the parameters and applicability domains covered; endpoint-specific guidance on toxicokinetics parameters required for read-across; case studies exemplifying how toxicokinetic data help support read-across. Activities to enhance the scientific robustness of read-across include the further user-friendly combination of read-across tools and formal guidance by the authorities specifying the minimum information requirements to justify read-across for a given toxicity endpoint. The EPAA was invited to continue dissemination activities and to explore possibilities to collate a contemporaneous list of open toxicokinetics tools that assist risk assessment.
  • Altres:

    Autor segons l'article: Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar V, Lostia A, Manou I, Monshouwer M, Müller BP, Paini A, Reid K, Rowan T, Sachana M, Schutte K, Stirling C, Taalman R, van Aerts L, Weissenhorn R, Sauer UG
    Departament: Enginyeria Química
    Autor/s de la URV: Kumar, Vikas
    Paraules clau: Weight-of-evidence (woe) threshold of toxicological concern (ttc) physiologically-based kinetic (pbk) modelling metabolism integrated approach for testing and assessment (iata) in vitro to in vivo extrapolation (ivive) hazard and risk assessment excretion (adme) distribution and elimination absorption
    Resum: The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based kinetic (PBK) models and to find synergies to enhance use of toxicokinetic data to strengthen read-across. Currently, lacking toxicokinetic data often prevent the application of read-across. Preferably, toxicokinetic data should be generated using in vitro and in silico tools and anchored towards human relevance. In certain sectors, PBK modelling is being used for risk assessment, but less so in others. Specific activities were identified to facilitate the use of in vitro and in silico toxicokinetic data to support read-across: The collation of available tools indicating the parameters and applicability domains covered; endpoint-specific guidance on toxicokinetics parameters required for read-across; case studies exemplifying how toxicokinetic data help support read-across. Activities to enhance the scientific robustness of read-across include the further user-friendly combination of read-across tools and formal guidance by the authorities specifying the minimum information requirements to justify read-across for a given toxicity endpoint. The EPAA was invited to continue dissemination activities and to explore possibilities to collate a contemporaneous list of open toxicokinetics tools that assist risk assessment.
    Àrees temàtiques: Toxicology Saúde coletiva Química Pharmacology & pharmacy Odontología Medicine, legal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 02732300
    Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat
    Identificador de l'autor: 0000-0002-9795-5967
    Pàgina final: 21
    Data d'alta del registre: 2024-09-07
    Volum de revista: 99
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0273230018302186
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Regulatory Toxicology And Pharmacology. 99 5-21
    Referència de l'ítem segons les normes APA: Laroche C, Aggarwal M, Bender H, Benndorf P, Birk B, Crozier J, Dal Negro G, De Gaetano F, Desaintes C, Gardner I, Hubesch B, Irizar A, John D, Kumar (2018). Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum. Regulatory Toxicology And Pharmacology, 99(), 5-21. DOI: 10.1016/j.yrtph.2018.08.006
    DOI de l'article: 10.1016/j.yrtph.2018.08.006
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Pàgina inicial: 5
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, Legal,Pharmacology & Pharmacy,Toxicology
    Weight-of-evidence (woe)
    threshold of toxicological concern (ttc)
    physiologically-based kinetic (pbk) modelling
    metabolism
    integrated approach for testing and assessment (iata)
    in vitro to in vivo extrapolation (ivive)
    hazard and risk assessment
    excretion (adme)
    distribution
    and elimination
    absorption
    Toxicology
    Saúde coletiva
    Química
    Pharmacology & pharmacy
    Odontología
    Medicine, legal
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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