Autor segons l'article: Parra, Sandra; Lopez-Dupla, Miguel; Ibarretxe, Daiana; de las Heras, Mercedes; Amigo, Nuria; Catala, Alba; Benavent, Marc; Garces, Esperanza; Navarro, Alvaro; Castro, Antoni
Departament: Medicina i Cirurgia
Autor/s de la URV: Castro Salomó, Antoni / Ibarretxe Gerediaga, Daiana / López Dupla, Jesús Miguel / Parra Pérez, Sandra
Paraules clau: Vascular stiffness Risk Recommendations Predictive value of tests Middle aged Male Lupus erythematosus, systemic Lipoproteins, hdl Intima-media thickness Independent predictor Immunoglobulin m Humans Female Dysfunction Disease-activity Damage Cross-sectional studies Cholesterol Biomarkers Beta 2-glycoprotein i Atherosclerosis Antimalarials Antibodies, anti-idiotypic Anti-igm Aged Adult
Resum: Objective To investigate the metabolic and immunologic factors associated with the presence of central arterial stiffness as measured by the augmentation index (AIx). Methods We conducted a cross-sectional study of 69 female patients with systemic lupus erythematosus (SLE) compared with a control group of 34 healthy women. The anthropometrical variables, the vascular studies, and the analytic data were obtained the same day. The AIx was assessed by peripheral arterial tonometry. The analysis of lipoprotein populations was performed using nuclear magnetic resonance (NMR) spectroscopy. Results Arterial stiffness was increased in patients with SLE compared with control subjects (mean +/- SD 20.30 +/- 21.54% versus 10.84 +/- 11.51%; P = 0.0021). Values for the AIx were correlated with the Framingham risk score (r = 0.481, P < 0.001), carotid intima-media thickness (r = 0.503, P < 0.001), systolic blood pressure (r = 0.270, P < 0.001), and age (r = 0.365, P < 0.001). Patients receiving antimalarial drugs had a lower AIx (mean +/- SD 11.74 +/- 11.28% versus 24.97 +/- 20.63%; P = 0.024). The AIx was correlated with the atherogenic lipoproteins analyzed by NMR. The immunologic variables associated with the AIx were C4 (r = 0.259, P = 0.046) and IgM anti-beta(2)-glycoprotein I (IgM anti-beta(2)GPI) (r = 0.284, P = 0.284). In the multivariate analysis, age (beta = 0.347, 95% confidence interval [95% CI] 0.020-0.669, P = 0.035), IgM beta(2)GPI (beta = 0.321, 95% CI 0.024-0.618, P = 0.035) and small dense high-density lipoprotein (HDL) particles (beta = 1.288, 95% CI 0.246-2.329, P = 0.017) predicted the AIx. Conclusion SLE patients had increased arterial stiffness compared with healthy control subjects. Arterial stiffness was decreased in patients treated with antimalarial drugs. Age, IgM beta(2)GPI, and the number of small dense HDL particles predicted the AIx.
Àrees temàtiques: Saúde coletiva Rheumatology Rehabilitation Psicología Medicina iii Medicina ii Medicina i General medicine Farmacia Educação física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2151464X
Adreça de correu electrònic de l'autor: daiana.ibarretxe@urv.cat sandra.parra@urv.cat antoni.castro@urv.cat jesusmiguel.lopez@urv.cat
Identificador de l'autor: 0000-0001-9363-6574 0000-0001-5441-6333 0000-0002-9141-2523
Pàgina final: 125
Data d'alta del registre: 2025-01-08
Volum de revista: 71
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Arthritis Care & Research. 71 (1): 116-125
Referència de l'ítem segons les normes APA: Parra, Sandra; Lopez-Dupla, Miguel; Ibarretxe, Daiana; de las Heras, Mercedes; Amigo, Nuria; Catala, Alba; Benavent, Marc; Garces, Esperanza; Navarro, (2019). Patients with systemic lupus erythematosus show an increased arterial stiffness that is predicted by IgM anti-β[2] -Glycoprotein I and small dense high-density lipoprotein particles. Arthritis Care & Research, 71(1), 116-125. DOI: 10.1002/acr.23594
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Pàgina inicial: 116
Tipus de publicació: Journal Publications
Repositori URV