Autor segons l'article: Tomas-Roig, J; Torrente, M; Cabre, M; Vilella, E; Colomina, M T
Departament: Bioquímica i Biotecnologia Psicologia
Autor/s de la URV: Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Torrente Torné, Margarita / Vilella Cuadrada, Elisabet
Paraules clau: Remyelination Oligodendroglia Neurobehavioral screening Myelination Myelin sheath Motor skills Motor coordination and anxiety Mice, inbred c57bl Mice Male Grooming Disease models, animal Demyelination Demyelinating diseases Cuprizone Central nervous system Brain Behavior, animal Animals neurobehavioral screening motor coordination and anxiety demyelination cuprizone
Resum: Destruction of the myelin sheath in the central nervous system (CNS) is prominent in many clinico-pathologic conditions. Among animal models that reproduce the pathological features of de- and remyelination processes, the mouse model of cuprizone administration is widely used. Both hyperactivity and motor impairment have been reported upon cuprizone exposure. The aim of the present study was to assess behaviour in mice after CPZ withdrawal.To summarize, animals showed hypo-activity and deficits in motor coordination when they were subjected to acute demyelinating insult while minor exploratory activity, impairment in motor coordination and lower anxiety levels emerged when remyelination was reached following cuprizone withdrawal. A recovery period of 6 weeks after removal of CPZ was not accompanied by a similar return of normal activity indicating long lasting behavioural effects caused by this neurotoxicant. Specifically, the recovery group showed impairments in neurological functions involved in sensorimotor, neuromuscular, motor coordination and the capacity to cope with a stress-inducing event.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01664328
Adreça de correu electrònic de l'autor: elisabet.vilella@urv.cat maria.cabre@urv.cat margarita.torrente@urv.cat mariateresa.colomina@urv.cat
Identificador de l'autor: 0000-0002-1887-5919 0000-0003-4124-8603 0000-0002-8901-6345 0000-0002-5619-4874
Data d'alta del registre: 2025-02-24
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Behavioural Brain Research. 363 38-44
Referència de l'ítem segons les normes APA: Tomas-Roig, J; Torrente, M; Cabre, M; Vilella, E; Colomina, M T (2019). Long lasting behavioural effects on cuprizone fed mice after neurotoxicant withdrawal.. Behavioural Brain Research, 363(), 38-44. DOI: 10.1016/j.bbr.2019.01.036
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV