Autor segons l'article: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Aros, Fernando; Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Fiol, Miquel; Lapetra, Jose; Elosua, Roberto; Maria Lamuela-Raventos, Rosa; Fito, Montserrat
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Smoking habit Sex factors Sex factor Sex Risk factors Risk factor Protein function Prediction Oxidation Obesity Non insulin dependent diabetes mellitus Middle aged Male Major clinical study Low density lipoprotein cholesterol Low density lipoprotein Lipoproteins, ldl Lipoproteins, hdl Hypertension Humans Human High density lipoprotein cholesterol High density lipoprotein Framingham risk score Female Dyslipidemias Dyslipidemia Disease association Diabetes mellitus, type 2 Diabetes mellitus Cross-sectional study Cross-sectional studies Controlled study Complication Cholesterol, ldl Cholesterol, hdl Cholesterol Cardiovascular risk Cardiovascular diseases Cardiovascular disease Body mass Blood Atherosclerosis Article Aged Age factors Age Adult
Resum: BACKGROUND: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. OBJECTIVE: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. METHODS: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. RESULTS: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). CONCLUSIONS: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.
Àrees temàtiques: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2025-02-18
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Plos One. 14 (6): e0218533-
Referència de l'ítem segons les normes APA: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; (2019). Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. Plos One, 14(6), e0218533-. DOI: 10.1371/journal.pone.0218533
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV