Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination

Autor segons l'article: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Aros, Fernando; Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Fiol, Miquel; Lapetra, Jose; Elosua, Roberto; Maria Lamuela-Raventos, Rosa; Fito, Montserrat

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Salas Salvadó, Jorge

Paraules clau: Smoking habit; Sex factors; Sex factor; Sex; Risk factors; Risk factor; Protein function; Prediction; Oxidation; Obesity; Non insulin dependent diabetes mellitus; Middle aged; Male; Major clinical study; Low density lipoprotein cholesterol; Low density lipoprotein; Lipoproteins, ldl; Lipoproteins, hdl; Hypertension; Humans; Human; High density lipoprotein cholesterol; High density lipoprotein; Framingham risk score; Female; Dyslipidemias; Dyslipidemia; Disease association; Diabetes mellitus, type 2; Diabetes mellitus; Cross-sectional study; Cross-sectional studies; Controlled study; Complication; Cholesterol, ldl; Cholesterol, hdl; Cholesterol; Cardiovascular risk; Cardiovascular diseases; Cardiovascular disease; Body mass; Blood; Atherosclerosis; Article; Aged; Age factors; Age; Adult

Resum: BACKGROUND: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. OBJECTIVE: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. METHODS: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. RESULTS: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). CONCLUSIONS: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.

Àrees temàtiques: Zootecnia / recursos pesqueiros; Sociology; Sociología; Serviço social; Saúde coletiva; Química; Psychology; Psicología; Planejamento urbano e regional / demografia; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Linguística e literatura; Letras / linguística; Interdisciplinary research in the social sciences; Interdisciplinar; Human geography and urban studies; History & philosophy of science; Historia; Geografía; Geociências; General medicine; General biochemistry,genetics and molecular biology; General agricultural and biological sciences; Farmacia; Environmental studies; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Educação; Economia; Direito; Demography; Comunicação e informação; Ciências sociais aplicadas i; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência política e relações internacionais; Ciência de alimentos; Ciência da computação; Biotecnología; Biology; Biodiversidade; Biochemistry, genetics and molecular biology (miscellaneous); Astronomia / física; Arquitetura, urbanismo e design; Archaeology; Antropologia / arqueologia; Anthropology; Agricultural and biological sciences (miscellaneous); Administração, ciências contábeis e turismo; Administração pública e de empresas, ciências contábeis e turismo

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Adreça de correu electrònic de l'autor: jordi.salas@urv.cat

Data d'alta del registre: 2025-02-18

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218533

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Plos One. 14 (6): e0218533-

Referència de l'ítem segons les normes APA: Hernaez, Alvaro; Trinidad Soria-Florido, Maria; Schroder, Helmut; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; (2019). Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. Plos One, 14(6), e0218533-. DOI: 10.1371/journal.pone.0218533

DOI de l'article: 10.1371/journal.pone.0218533

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2019

Tipus de publicació: Journal Publications