Autor segons l'article: Miro-Blanch, Joan; Yanes, Oscar
Departament: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: Miró Blanch, Joan / Yanes Torrado, Óscar
Paraules clau: Transplantation Transcription Posttranslational modifications Open chromatin Omics Microbiota Metabolomics Metabolism Impact Histones Epigenetics Donor feces Dna Diet-induced obesity Bacteria Acetylation
Resum: Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Molecular medicine Medicina veterinaria Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16648021
Adreça de correu electrònic de l'autor: oscar.yanes@urv.cat joan.miro@estudiants.urv.cat
Identificador de l'autor: 0000-0003-3695-7157 0000-0003-3179-0554
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fgene.2019.00638/full
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Frontiers In Genetics. 10 (JUL): 638-638
Referència de l'ítem segons les normes APA: Miro-Blanch, Joan; Yanes, Oscar (2019). Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Frontiers In Genetics, 10(JUL), 638-638. DOI: 10.3389/fgene.2019.00638
DOI de l'article: 10.3389/fgene.2019.00638
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications