Articles producció científica> Medicina i Cirurgia

Maternal and Cord Blood Adiponectin Multimeric Forms in Gestational Diabetes Mellitus: A prospective analysis

  • Dades identificatives

    Identificador: imarina:5899124
    Autors:
    Ballesteros, MonicaSimon, InmaculadaVendrell, JoanCeperuelo-Mallafre, VictoriaMiralles, Ramon MAlbaiges, GerardTinahones, FranciscoMegia, Ana
    Resum:
    OBJECTIVE-To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) pregnant women. RESEARCH DESIGN AND METHODS-A total of 212 women with a singleton pregnancy, 132 with NGT and 80 with GDM, and their offspring were studied. Maternal blood was obtained in the early third trimester and cord blood was obtained at delivery. Total adiponectin and the multimeric forms of adiponectin were determined in cord blood and maternal serum. Spearman rank correlation and stepwise linear correlation analysis were used to assess the relationship between cbAdiponectin levels and clinical and analytical parameters. RESULTS-No differences in cbAdiponectin concentration or its multimeric forms were observed in the offspring of diabetic mothers compared with NGT mothers. The HMW-to-total adiponectin ratio was higher in cord blood than in maternal serum, whereas the MMW- and LMW-to-total adiponectin ratio was lower. Cord blood total and HMW adiponectin levels were positively correlated with birth weight and the ponderal index (PI), whereas cord blood MMW adiponectin was negatively correlated with the PI. In addition, cbAdiponectin and its multimeric forms were correlated with mAdiponectin concentrations. In the multivariate analysis, maternal multimeric forms of adiponectin emerged as independent predictors of cbAdiponectin, its multimers, and their distribution. CONCLUSIONS-cbAdiponectin concentrations are independently related to mAdiponectin levels and unrelated to the diagnosis of GDM. Maternal multimeric forms of adiponectin are independent
  • Altres:

    Autor segons l'article: Ballesteros, Monica; Simon, Inmaculada; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; Miralles, Ramon M; Albaiges, Gerard; Tinahones, Francisco; Megia, Ana
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Albaigès Baiget, Gerard / Ballesteros Pérez, Monica / Ceperuelo Mallafré, Maria Victoria / Megía Colet, Ana / MIRALLES PI, RAMÓN MARÍA / Simón Muela, María Inmaculada / Vendrell Ortega, Juan José
    Paraules clau: Serum adiponectin Plasma adiponectin Insulin-resistance Glucose Expression Birth-weight
    Resum: OBJECTIVE-To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) pregnant women. RESEARCH DESIGN AND METHODS-A total of 212 women with a singleton pregnancy, 132 with NGT and 80 with GDM, and their offspring were studied. Maternal blood was obtained in the early third trimester and cord blood was obtained at delivery. Total adiponectin and the multimeric forms of adiponectin were determined in cord blood and maternal serum. Spearman rank correlation and stepwise linear correlation analysis were used to assess the relationship between cbAdiponectin levels and clinical and analytical parameters. RESULTS-No differences in cbAdiponectin concentration or its multimeric forms were observed in the offspring of diabetic mothers compared with NGT mothers. The HMW-to-total adiponectin ratio was higher in cord blood than in maternal serum, whereas the MMW- and LMW-to-total adiponectin ratio was lower. Cord blood total and HMW adiponectin levels were positively correlated with birth weight and the ponderal index (PI), whereas cord blood MMW adiponectin was negatively correlated with the PI. In addition, cbAdiponectin and its multimeric forms were correlated with mAdiponectin concentrations. In the multivariate analysis, maternal multimeric forms of adiponectin emerged as independent predictors of cbAdiponectin, its multimers, and their distribution. CONCLUSIONS-cbAdiponectin concentrations are independently related to mAdiponectin levels and unrelated to the diagnosis of GDM. Maternal multimeric forms of adiponectin are independent predictors of the concentrations of cbAdiponectin and its multimeric forms at delivery.
    Àrees temàtiques: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: victoria.ceperuelo@urv.cat monica.ballesteros@urv.cat ana.megia@urv.cat jvortega@iispv.cat
    Identificador de l'autor: 0000-0002-4460-9761 0000-0002-5101-9452 0000-0002-6994-6115
    Data d'alta del registre: 2025-01-08
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Diabetes Care. 34 (11): 2418-2423
    Referència de l'ítem segons les normes APA: Ballesteros, Monica; Simon, Inmaculada; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; Miralles, Ramon M; Albaiges, Gerard; Tinahones, Francisco; Megia (2011). Maternal and Cord Blood Adiponectin Multimeric Forms in Gestational Diabetes Mellitus: A prospective analysis . Diabetes Care, 34(11), 2418-2423. DOI: 10.2337/dc11-0788
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2011
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Serum adiponectin
    Plasma adiponectin
    Insulin-resistance
    Glucose
    Expression
    Birth-weight
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing
  • Documents:

  • Cerca a google

    Search to google scholar