Autor segons l'article: Razquin, Cristina; Ruiz-Canela, Miguel; Clish, Clary B; Li, Jun; Toledo, Estefania; Dennis, Courtney; Liang, Liming; Salas-Huetos, Albert; Pierce, Kerry A; Guasch-Ferre, Marta; Corella, Dolores; Ros, Emilio; Estruch, Ramon; Gomez-Gracia, Enrique; Fito, Montse; Lapetra, Jose; Romaguera, Dora; Alonso-Gomez, Angel; Serra-Majem, Lluis; Salas-Salvado, Jordi; Hu, Frank B; Martinez-Gonzalez, Miguel A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Huetos, Albert / Salas Salvadó, Jorge
Paraules clau: Type 2 diabetes; Prevention; Metabolites; Dietary intervention; Cardiovascular disease; Biomarkers; 2-aminoadipic acid; metabolites; dietary intervention; cardiovascular disease; biomarkers
Resum: BACKGROUND: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the effect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the effects of these metabolites on CVD or T2D risk. METHODS: Two unstratified case-cohort studies nested within the PREDIMED trial were used. For CVD analyses, we selected 696 non-cases and 221 incident CVD cases; for T2D, we included 610 non-cases and 243 type 2 diabetes incident cases. Metabolites were quantified using liquid chromatography-tandem mass spectrometry, at baseline and after 1-year of intervention. RESULTS: In weighted Cox regression models, we found that baseline lysine (HR+1 SD increase = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR+1 SD increase = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. A significant interaction (p = 0.032) between baseline lysine and T2D on the risk of CVD was observed: subjects with prevalent T2D and high levels of lysine exhibited the highest risk of CVD. The intervention with MedDiet did not have a significant effect on 1-year changes of the metabolites. CONCLUSIONS: Our results provide an independent prospective replication of the association of 2-AAA with future risk of T2D. We show an association of lysine with subsequent CVD risk, which is apparently diabetes-dependent. No evidence of effects of MedDiet intervention on lysine, 2-AAA or pipecolic acid changes was found. Trial registration ISRCTN35739639; registration date: 05/10/2005; recruitment start date 01/10/2003.
Àrees temàtiques: Saúde coletiva; Medicina ii; Medicina i; Internal medicine; Interdisciplinar; Farmacia; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Educação física; Ciências biológicas ii; Ciências biológicas i; Cardiology and cardiovascular medicine; Cardiac & cardiovascular systems; Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752840
Adreça de correu electrònic de l'autor: albert.salas@urv.cat; jordi.salas@urv.cat
Data d'alta del registre: 2025-02-18
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://cardiab.biomedcentral.com/articles/10.1186/s12933-019-0958-2
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Cardiovascular Diabetology. 18 (1): 151-
Referència de l'ítem segons les normes APA: Razquin, Cristina; Ruiz-Canela, Miguel; Clish, Clary B; Li, Jun; Toledo, Estefania; Dennis, Courtney; Liang, Liming; Salas-Huetos, Albert; Pierce, Ker (2019). Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies. Cardiovascular Diabetology, 18(1), 151-. DOI: 10.1186/s12933-019-0958-2
DOI de l'article: 10.1186/s12933-019-0958-2
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV