Autor segons l'article: Hereu, Merce; Ramos-Romero, Sara; Marin-Valls, Roser; Amezqueta, Susana; Miralles-Perez, Bernat; Romeu, Marta; Mendez, Lucia; Medina, Isabel; Lluis Torres, Josep;
Departament: Ciències Mèdiques Bàsiques
e-ISSN: 2072-6643
Autor/s de la URV: Miralles Pérez, Bernat / Romeu Ferran, Marta
Paraules clau: Wistar Weight Prevotella Polyunsaturated fatty-acids Omega-3 pufas Model Microbiota Metabolites Lactobacillus Insulin-resistance Impact Iminosugar Iminocyclitol Gut microbiota Diet D-fagomine Bacteroides Acetate ?-3 pufas weight prevotella iminosugar iminocyclitol gut microbiota d-fagomine bacteroides
Resum: Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of D-fagomine and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA 1:1) on putatively beneficial gut bacterial strains. Male Sprague-Dawley rats were supplemented with D-fagomine, omega-3 PUFAs, or both, for 23 weeks. Bacterial subgroups were evaluated in fecal DNA by quantitative real-time polymerase chain reaction (qRT-PCR) and short-chain fatty acids were determined by gas chromatography. We found that the populations of the genus Prevotella remained stable over time in animals supplemented with D-fagomine, independently of omega-3 PUFA supplementation. Animals in these groups gained less weight than controls and rats given only omega-3 PUFAs. D-Fagomine supplementation together with omega-3 PUFAs maintained the relative populations of Bacteroides. omega-3 PUFAs alone or combined with D-fagomine reduced the amount of acetic acid and total short-chain fatty acids in feces. The plasma levels of pro-inflammatory arachidonic acid derived metabolites, triglycerides and cholesterol were lower in both groups supplemented with omega-3 PUFAs. The D-fagomine and omega-3 PUFAs combination provided the functional benefits of each supplement. Notably, it helped stabilize populations of Prevotella in the rat intestinal tract while reducing weight gain and providing the anti-inflammatory and cardiovascular benefits of omega-3 PUFAs.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Adreça de correu electrònic de l'autor: bmirallesperez@gmail.com marta.romeu@urv.cat
Identificador de l'autor: 0000-0003-1294-7069 0000-0002-2131-1858
Data d'alta del registre: 2024-10-26
Volum de revista: 11
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6643/11/11/2606
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nutrients. 11 (11):
Referència de l'ítem segons les normes APA: Hereu, Merce; Ramos-Romero, Sara; Marin-Valls, Roser; Amezqueta, Susana; Miralles-Perez, Bernat; Romeu, Marta; Mendez, Lucia; Medina, Isabel; Lluis To (2019). Combined Buckwheat D-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats. Nutrients, 11(11), -. DOI: 10.3390/nu11112606
DOI de l'article: 10.3390/nu11112606
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV