e-ISSN: 1638-6183
Codi de projecte: 713679
Paraules clau: Women Serum Reus-tarragona birth cohort Red blood cell folate Polymorphisms Miscarriage Microbiological assay Metabolism Maternal homocysteine Homocysteine History Folate Early-pregnancy Early pregnancy Conception red blood cell folate miscarriage homocysteine early pregnancy
Data d'alta del registre: 2023-10-07
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Referència a l'article segons font original: Biochimie. 173 62-67
Referència de l'ítem segons les normes APA: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy M (2020). Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study. Biochimie, 173(), 62-67. DOI: 10.1016/j.biochi.2020.01.008
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Acrònim: MFP-COFUND
Tipus de publicació: Journal Publications
Autor segons l'article: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy MM
Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/s de la URV: Ballesteros Pérez, Monica / Cavallé Busquets, Pere / Fernández Ballart, Joan Domènech / Haro Barceló, Júlia / Murphy, Michelle / Ramos Rodríguez, Carla / Rojas Gómez, Alejandra
Resum: © 2020 The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 μmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 μmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.
Àrees temàtiques: Zootecnia / recursos pesqueiros Química Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03009084
Adreça de correu electrònic de l'autor: monica.ballesteros@urv.cat carla.ramos@urv.cat pere.cavalleb@urv.cat michelle.murphy@urv.cat carla.ramos@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat
Identificador de l'autor: 0000-0002-6304-6204 0000-0003-4427-2852 0000-0003-4427-2852 0000-0003-4427-2852
Data de publicació de l'article: 18 january 2020
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0300908420300109?via%3Dihub
Programa de finançament: European Union Horizon 2020
DOI de l'article: 10.1016/j.biochi.2020.01.008
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Acció del programa de finançament: Marie Skłodowska-Curie