Articles producció científica> Medicina i Cirurgia

Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study

  • Dades identificatives

    Identificador: imarina:6111254
    Autors:
    Cavallé-Busquets PInglès-Puig MFernandez-Ballart JDHaro-Barceló JRojas-Gómez ARamos-Rodriguez CBallesteros MMeyer KUeland PMMurphy MM
    Resum:
    © 2020 The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 μmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 μmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.
  • Altres:

    e-ISSN: 1638-6183
    Codi de projecte: 713679
    Paraules clau: Women Serum Reus-tarragona birth cohort Red blood cell folate Polymorphisms Miscarriage Microbiological assay Metabolism Maternal homocysteine Homocysteine History Folate Early-pregnancy Early pregnancy Conception red blood cell folate miscarriage homocysteine early pregnancy
    Data d'alta del registre: 2023-10-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Referència a l'article segons font original: Biochimie. 173 62-67
    Referència de l'ítem segons les normes APA: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy M (2020). Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study. Biochimie, 173(), 62-67. DOI: 10.1016/j.biochi.2020.01.008
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrònim: MFP-COFUND
    Tipus de publicació: Journal Publications
    Autor segons l'article: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy MM
    Departament: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    Autor/s de la URV: Ballesteros Pérez, Monica / Cavallé Busquets, Pere / Fernández Ballart, Joan Domènech / Haro Barceló, Júlia / Murphy, Michelle / Ramos Rodríguez, Carla / Rojas Gómez, Alejandra
    Resum: © 2020 The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 μmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 μmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Química Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 03009084
    Adreça de correu electrònic de l'autor: monica.ballesteros@urv.cat carla.ramos@urv.cat pere.cavalleb@urv.cat michelle.murphy@urv.cat carla.ramos@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat
    Identificador de l'autor: 0000-0002-6304-6204 0000-0003-4427-2852 0000-0003-4427-2852 0000-0003-4427-2852
    Data de publicació de l'article: 18 january 2020
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0300908420300109?via%3Dihub
    Programa de finançament: European Union Horizon 2020
    DOI de l'article: 10.1016/j.biochi.2020.01.008
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Acció del programa de finançament: Marie Skłodowska-Curie
  • Paraules clau:

    Biochemistry,Biochemistry & Molecular Biology,Medicine (Miscellaneous)
    Women
    Serum
    Reus-tarragona birth cohort
    Red blood cell folate
    Polymorphisms
    Miscarriage
    Microbiological assay
    Metabolism
    Maternal homocysteine
    Homocysteine
    History
    Folate
    Early-pregnancy
    Early pregnancy
    Conception
    red blood cell folate
    miscarriage
    homocysteine
    early pregnancy
    Zootecnia / recursos pesqueiros
    Química
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Farmacia
    Engenharias iv
    Engenharias ii
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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