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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

  • Dades identificatives

    Identificador: imarina:6311211
    Autors:
    Autrup HBarile FABerry SCBlaauboer BJBoobis ABolt HBorgert CJDekant WDietrich DDomingo JLGori GBGreim HHengstler JKacew SMarquardt HPelkonen OSavolainen KHeslop-Harrison PVermeulen NP
    Resum:
    © 2020 Elsevier B.V. Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
  • Altres:

    Autor segons l'article: Autrup H; Barile FA; Berry SC; Blaauboer BJ; Boobis A; Bolt H; Borgert CJ; Dekant W; Dietrich D; Domingo JL; Gori GB; Greim H; Hengstler J; Kacew S; Marquardt H; Pelkonen O; Savolainen K; Heslop-Harrison P; Vermeulen NP
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Domingo Roig, José Luis
    Paraules clau: endocrine disruption risk characterisation Bisphenol-a Endocrine disruption Estrogens Eu Human health Modulators Risk characterisation Science Testing Uncertainty
    Resum: © 2020 Elsevier B.V. Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.
    Àrees temàtiques: Astronomia / física Biodiversidade Biotecnología Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Engenharias ii Ensino Environmental sciences Farmacia Geociências Geografía Health, toxicology and mutagenesis Interdisciplinar Materiais Medicina i Medicina ii Medicina veterinaria Medicine (miscellaneous) Odontología Pharmacology Pharmacology & pharmacy Psicología Química Toxicology Zootecnia / recursos pesqueiros
    Adreça de correu electrònic de l'autor: joseluis.domingo@urv.cat
    ISSN: 13826689
    Identificador de l'autor: 0000-0001-6647-9470
    Data d'alta del registre: 2023-02-22
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1382668920300727?via%3Dihub
    Referència a l'article segons font original: Environmental Toxicology And Pharmacology. 78 (103396): 103396-
    Referència de l'ítem segons les normes APA: Autrup H; Barile FA; Berry SC; Blaauboer BJ; Boobis A; Bolt H; Borgert CJ; Dekant W; Dietrich D; Domingo JL; Gori GB; Greim H; Hengstler J; Kacew S; M (2020). Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?. Environmental Toxicology And Pharmacology, 78(103396), 103396-. DOI: 10.1016/j.etap.2020.103396
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1016/j.etap.2020.103396
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Medicine (Miscellaneous),Pharmacology,Pharmacology & Pharmacy,Toxicology
    endocrine disruption
    risk characterisation
    Bisphenol-a
    Endocrine disruption
    Estrogens
    Eu
    Human health
    Modulators
    Risk characterisation
    Science
    Testing
    Uncertainty
    Astronomia / física
    Biodiversidade
    Biotecnología
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Engenharias ii
    Ensino
    Environmental sciences
    Farmacia
    Geociências
    Geografía
    Health, toxicology and mutagenesis
    Interdisciplinar
    Materiais
    Medicina i
    Medicina ii
    Medicina veterinaria
    Medicine (miscellaneous)
    Odontología
    Pharmacology
    Pharmacology & pharmacy
    Psicología
    Química
    Toxicology
    Zootecnia / recursos pesqueiros
    13826689
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