Autor segons l'article: Salas-Salvado, Jordi; Farres, Xavier; Luque, Xavier; Narejos, Silvia; Borrell, Manel; Basora, Josep; Anguera, Anna; Torres, Ferran; Bullo, Monica; Balanza, Rafel
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Balanza Roure, Rafael Juan / Basora Gallisa, Josep / Bulló Bonet, Mònica / CASAS AGUSTENCH, PATRICIA / Salas Salvadó, Jorge
Paraules clau: Plantago Lipid profile Glucomannan Dietary fibre Body weight
Resum: The aim of the study was to compare the effect of the administration of a mixture of fibres on body weight-loss, satiety, lipid profile and glucose metabolism. We included 200 overweight or obese patients in a parallel, double-blind, placebo-controlled clinical trial, who were randomised to receive, in the context of an energy-restricted diet for a period of 16 weeks, a mixed fibre dose (3 g Plantago ovata husk and 1 g glucomannan) twice (b.i.d. group) or three times daily (t.i.d. group) or placebo. Weight change was the primary efficacy endpoint. Satiety, dietary compliance, lipid profile, glucose tolerance, insulin resistance and high-sensitivity C-reactive protein were secondary endpoints. Weight loss tended to be higher after both doses of fibre (-4.52 (SD 0.56) and -4.60 (SD 0.55) kg) than placebo (-0.79 (SD 0.58) kg); the differences in changes between groups were not statistically significant. Postprandial satiety increased in both fibre groups compared to the placebo. The differences between groups in LDL-cholesterol levels were significant (P = 0.03), with greater reductions in the two fibre-supplemented groups (-0.38 (SD 0.10) and -0.24 (SD 0.09) mmol/l in the b.i.d. and t.i.d. groups v. -0.06 (SD 0.09) mmol/l in placebo group). A similar pattern was observed for changes in total cholesterol:HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratios. Interventions were well tolerated and had no effects on HDL-cholesterol, glucose and insulin concentrations, glucose tolerance or high-sensitivity C-reactive protein. In conclusion, a 16-week dietary supplement of soluble fibre in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some CVD risk factors, the most important of which was a significant decrease in plasma LDL-cholesterol concentrations. © The Authors 2007.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14752662
Adreça de correu electrònic de l'autor: josep.basora@urv.cat rafaeljuan.balanza@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: British Journal Of Nutrition. 99 (6): 1380-1387
Referència de l'ítem segons les normes APA: Salas-Salvado, Jordi; Farres, Xavier; Luque, Xavier; Narejos, Silvia; Borrell, Manel; Basora, Josep; Anguera, Anna; Torres, Ferran; Bullo, Monica; Bal (2008). Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: A randomised trial. British Journal Of Nutrition, 99(6), 1380-1387. DOI: 10.1017/S0007114507868528
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2008
Tipus de publicació: Journal Publications
Repositori URV