Autor segons l'article: Rue M; Vilaprinyo E; Lee S; Martinez-Alonso M; Carles M; Marcos-Gragera R; Pla R; Espinas J
Departament: Economia
Autor/s de la URV: Carles Lavila, Misericòrdia / Espinas Pinol, Josep Alfons / Pla Farnòs, Roger Jesús
Paraules clau: Deteccion precoz Cáncer de mama
Resum: Background: At present, it is complicated to use screening trials to determine the optimal age intervals and periodicities of breast cancer early detection. Mathematical models are an alternative that has been widely used. The aim of this study was to estimate the effect of different breast cancer early detection strategies in Catalonia (Spain), in terms of breast cancer mortality reduction (MR) and years of life gained (YLG), using the stochastic models developed by Lee and Zelen (LZ). Methods: We used the LZ model to estimate the cumulative probability of death for a cohort exposed to different screening strategies after T years of follow-up. We also obtained the cumulative probability of death for a cohort with no screening. These probabilities were used to estimate the possible breast cancer MR and YLG by age, period and cohort of birth. The inputs of the model were: incidence of, mortality from and survival after breast cancer, mortality from other causes, distribution of breast cancer stages at diagnosis and sensitivity of mammography. The outputs were relative breast cancer MR and YLG. Results: Relative breast cancer MR varied from 20% for biennial exams in the 50 to 69 age interval to 30% for annual exams in the 40 to 74 age interval. When strategies differ in periodicity but not in the age interval of exams, biennial screening achieved almost 80% of the annual screening MR. In contrast to MR, the effect on YLG of extending screening from 69 to 74 years of age was smaller than the effect of extending the screening from 50 to 45 or 40 years. Conclusion: In this study we have obtained a measure of the effect of breast cancer screening in terms of mortality and years of life gained. The Lee and Zelen mathematical models have been very useful for assessing the impact of different modalities of early detection on MR and YLG in Catalonia (Spain). © 2009 Rue et al; licensee BioMed Central Ltd.
Àrees temàtiques: Saúde coletiva Química Planejamento urbano e regional / demografia Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics Farmacia Ensino Engenharias iii Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cancer research Biotecnología Biodiversidade Administração, ciências contábeis e turismo
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1471-2407
Adreça de correu electrònic de l'autor: rogerjesus.pla@urv.cat misericordia.carles@urv.cat
Identificador de l'autor: 0000-0002-3727-8933 0000-0003-3796-3014
Data d'alta del registre: 2024-09-28
Volum de revista: 9
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-326
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Bmc Cancer. 9 326-
Referència de l'ítem segons les normes APA: Rue M; Vilaprinyo E; Lee S; Martinez-Alonso M; Carles M; Marcos-Gragera R; Pla R; Espinas J (2009). Effectiveness of early detection on breast cancer mortality reduction in Catalonia (Spain). Bmc Cancer, 9(), 326-. DOI: 10.1186/1471-2407-9-326
DOI de l'article: 10.1186/1471-2407-9-326
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2009
Tipus de publicació: Journal Publications
Repositori URV