Articles producció científica> Infermeria

Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis

  • Dades identificatives

    Identificador: imarina:6488979
    Autors:
    Montalvo, ItziarGonzalez-Rodriguez, AlexandreCabezas, AngelGutierrez-Zotes, AlfonsoSole, MontseAlgora, Maria JoseOrtega, LauraMartorell, LourdesSanchez-Gistau, VanessaVilella, ElisabetLabad, Javier
    Resum:
    Background Glucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA) axis measures. Methods Sixty ROP outpatients and 50 healthy subjects (HS) were studied. Cognitive function was assessed with the MATRICS Consensus Cognitive Battery. Glycated haemoglobin (HbA1(c)), glucose, insulin, and C-peptide levels were determined in plasma. The HOMA-insulin resistance index was calculated. Salivary samples were obtained at home on another day to assess the cortisol awakening response and cortisol levels during the day. Univariate analyses were conducted to explore the association between glucose metabolism parameters and cognitive tasks. For those parameters that were more clearly associated with the cognitive outcome, multiple linear regression analyses were conducted to adjust for covariates. Each cognitive task was considered the dependent variable. Covariates were age, sex, education level, diagnosis, antipsychotic and benzodiazepine treatment, body mass index (BMI), smoking, and HPA axis measures. Potential interactions between diagnosis and glucose parameters were tested. Results There were no significant differences in HPA axis measures or glucose parameters, with the exception of C-peptide (that was higher in ROP patients), between groups. ROP patients had a lower performance than HS in all cognitive tasks (p < 0.01 for all tasks). Of all glucose metabolism parameters, HbA1c levels were more clearly associated with cognitive impairment in cognitive tasks dealing with executive functions and visual memory in both ROP patients and HS. Multivaria
  • Altres:

    Autor segons l'article: Montalvo, Itziar; Gonzalez-Rodriguez, Alexandre; Cabezas, Angel; Gutierrez-Zotes, Alfonso; Sole, Montse; Algora, Maria Jose; Ortega, Laura; Martorell, Lourdes; Sanchez-Gistau, Vanessa; Vilella, Elisabet; Labad, Javier;
    Departament: Infermeria
    Autor/s de la URV: Martorell Bonet, Lourdes / Ortega Sanz, Laura / Vilella Cuadrada, Elisabet
    Paraules clau: Type-2 diabetes-mellitus Serum interleukin-6 Risk Insulin Impairment Glycated haemoglobin Glucose-tolerance Glucose Free-thyroxine levels Early psychosis Drug-naive patients Cortisol awakening response Cortisol Cognition 1st-episode schizophrenia glucose early psychosis cortisol cognition
    Resum: Background Glucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA) axis measures. Methods Sixty ROP outpatients and 50 healthy subjects (HS) were studied. Cognitive function was assessed with the MATRICS Consensus Cognitive Battery. Glycated haemoglobin (HbA1(c)), glucose, insulin, and C-peptide levels were determined in plasma. The HOMA-insulin resistance index was calculated. Salivary samples were obtained at home on another day to assess the cortisol awakening response and cortisol levels during the day. Univariate analyses were conducted to explore the association between glucose metabolism parameters and cognitive tasks. For those parameters that were more clearly associated with the cognitive outcome, multiple linear regression analyses were conducted to adjust for covariates. Each cognitive task was considered the dependent variable. Covariates were age, sex, education level, diagnosis, antipsychotic and benzodiazepine treatment, body mass index (BMI), smoking, and HPA axis measures. Potential interactions between diagnosis and glucose parameters were tested. Results There were no significant differences in HPA axis measures or glucose parameters, with the exception of C-peptide (that was higher in ROP patients), between groups. ROP patients had a lower performance than HS in all cognitive tasks (p < 0.01 for all tasks). Of all glucose metabolism parameters, HbA1c levels were more clearly associated with cognitive impairment in cognitive tasks dealing with executive functions and visual memory in both ROP patients and HS. Multivariate analyses found a significant negative association between HbA1c and cognitive functioning in five cognitive tasks dealing with executive functions, visual memory and attention/vigilance (a ROP diagnosis by HbA1(c) negative interaction was found in this latter cognitive domain, suggesting that HBA1(c) levels are associated with impaired attention only in ROP patients). Conclusions Our study found that HbA1(c) was negatively associated with cognitive functioning in both ROP patients and HS in tasks dealing with executive functions and visual memory. In ROP patients, HbA1(c) was also associated with impaired attention. These results were independent of BMI and measures of HPA axis activity.
    Àrees temàtiques: Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Interdisciplinar Ensino Engenharias iv Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    ISSN: 16640640
    Adreça de correu electrònic de l'autor: laura.ortega@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat
    Identificador de l'autor: 0000-0003-2476-7700 0000-0003-4999-2197 0000-0002-1887-5919
    Data d'alta del registre: 2024-01-13
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00455/full
    Referència a l'article segons font original: Frontiers In Psychiatry. 11 (455): 455-
    Referència de l'ítem segons les normes APA: Montalvo, Itziar; Gonzalez-Rodriguez, Alexandre; Cabezas, Angel; Gutierrez-Zotes, Alfonso; Sole, Montse; Algora, Maria Jose; Ortega, Laura; Martorell, (2020). Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis. Frontiers In Psychiatry, 11(455), 455-. DOI: 10.3389/fpsyt.2020.00455
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3389/fpsyt.2020.00455
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Psychiatry,Psychiatry and Mental Health
    Type-2 diabetes-mellitus
    Serum interleukin-6
    Risk
    Insulin
    Impairment
    Glycated haemoglobin
    Glucose-tolerance
    Glucose
    Free-thyroxine levels
    Early psychosis
    Drug-naive patients
    Cortisol awakening response
    Cortisol
    Cognition
    1st-episode schizophrenia
    glucose
    early psychosis
    cortisol
    cognition
    Psychiatry and mental health
    Psychiatry
    Psicología
    Medicina ii
    Medicina i
    Interdisciplinar
    Ensino
    Engenharias iv
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
  • Documents:

  • Cerca a google

    Search to google scholar