Autor segons l'article: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Muguerza; Gerard Aragonès
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Aragonès Bargalló, Gerard / ARDID RUIZ, ANDREA / GIBERT RAMOS, ALBERT / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Rodríguez Gómez, Miquel Àngel / Suárez Recio, Manuel
Paraules clau: Supplementation Resistance Protein Proanthocyanidins Obesity Multi-ingredient Liver Inhibition Induced obesity Hypothalamic sirt1 Fat Conjugated linoleic-acid Conjugated linoleic acid Bioactive peptides Anthocyanidins
Resum: The use of a single family of dietary bioactive compounds has not been sufficient to manage highly regulated mechanisms such as body weight. Therefore, we aimed to evaluate the effect of a multifunctional ingredient (MIX) based on the co-administration of a low dose of conjugated linoleic acid with the protein hydrolysate from chicken feet, Hpp11, and a mixture of grape-seed proanthocyanidins and berry anthocyanins on body weight management in obese rats fed a cafeteria diet. The daily oral administration of the MIX for three weeks significantly reversed obesity and hyperleptinemia and increased energy expenditure and fat oxidation. In addition, animals administered the MIX exhibited greater hypothalamic activation of STAT3 in POMC-expressing neurons than non-supplemented animals. Our results strongly suggest that the co-administration of different bioactive compounds could be a promising strategy to complement the existing therapies against obesity and leptin resistance.
Àrees temàtiques: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 17564646
Adreça de correu electrònic de l'autor: begona.muguerza@urv.cat gerard.aragones@urv.cat miquelangel.rodriguez@alumni.urv.cat manuel.suarez@urv.cat
Identificador de l'autor: 0000-0001-7384-8588 0000-0003-0122-8253
Data d'alta del registre: 2023-12-16
Volum de revista: 73
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: Journal Of Functional Foods. 73 (104141):
Referència de l'ítem segons les normes APA: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Mugue (2020). A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats. Journal Of Functional Foods, 73(104141), -. DOI: 10.1016/j.jff.2020.104141
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV