Repositori URV

Identificador: imarina:7980030

Handle: https://hdl.handle.net/20.500.11797/imarina7980030

Autors:
Navarrete-Munoz, Eva-MariaVioque, JesusToledo, EstefaniaOncina-Canovas, AlejandoAngel Martinez-Gonzalez, MiguelSalas-Salvado, JordiCorella, DoloresFito, MontserratRomaguera, DoraAlonso-Gomez, Angel MWarnberg, JuliaAlfredo Martinez, JSerra-Majem, LuisEstruch, RamonTinahones, Francisco JLapetra, JosePinto, XavierTur, Josep ALopez-Miranda, JoseBueno-Cavanillas, AuroraMatia-Martin, PilarDaimiel, LidiaMartin Sanchez, VicenteVidal, Josepde Cos Blanco, Ana IsabelRos, EmiliDiez-Espino, JavierBabio, NancyFernandez-Carrion, RebecaCastaner, OlgaColom, AntoniCompan-Gabucio, LauraSalaverria Lete, ItziarCrespo-Oliva, EdelysAbete, ItziarTomaino, LauraCasas, RosaCarlos Fernandez-Garcia, JoseManuel Santos-Lozano, JoseSarasa, IziarAntonio Garcia-Rios, Jose MMartin-Pelaez, SandraRuiz-Canela, MiguelDiaz-Lopez, AndresMartinez-Lacruz, RaulDolors Zomeno, MariaRayo, ElenaGisbert Selles, CristinaCanudas, SilviaGoday, AlbertGarcia-de-la-Hera, Manoli

Resum:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.