Articles producció científica> Enginyeria Química

Ciprofloxacin and graphene oxide combination-New face of a known drug

  • Dades identificatives

    Identificador: imarina:9002811
    Autors:
    Matulewicz KKaźmierski ŁWiśniewski MRoszkowski SRoszkowski KKowalczyk ORoy ATylkowski BBajek A
    Resum:
    © 2020 by the authors. Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.
  • Altres:

    Autor segons l'article: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A
    Departament: Enginyeria Química
    Autor/s de la URV: Tylkowski, Bartosz
    Paraules clau: Size Nanosheets In-vitro Graphene oxide Drug modification Delivery Carrier Carbon-based materials Anticancer drug Accumulation
    Resum: © 2020 by the authors. Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.
    Àrees temàtiques: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: bartosz.tylkowski@urv.cat
    Identificador de l'autor: 0000-0002-4163-0178
    Data d'alta del registre: 2023-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/1996-1944/13/19/4224
    Referència a l'article segons font original: Materials. 13 (19):
    Referència de l'ítem segons les normes APA: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A (2020). Ciprofloxacin and graphene oxide combination-New face of a known drug. Materials, 13(19), -. DOI: 10.3390/MA13194224
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.3390/MA13194224
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry, Physical,Condensed Matter Physics,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Metallurgy & Metallurgical Engineering,Physics, Applied,Physics, Condensed Matter
    Size
    Nanosheets
    In-vitro
    Graphene oxide
    Drug modification
    Delivery
    Carrier
    Carbon-based materials
    Anticancer drug
    Accumulation
    Physics, condensed matter
    Physics, applied
    Metallurgy & metallurgical engineering
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Condensed matter physics
    Chemistry, physical
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