Articles producció científica> Bioquímica i Biotecnologia

Large gene overlaps in prokaryotic genomes: result of functional constraints or mispredictions?

  • Dades identificatives

    Identificador: imarina:9048004
    Handle: https://hdl.handle.net/20.500.11797/imarina9048004
    Autors:
    Resum:
    Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.

  • Altres:

    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Departament: Bioquímica i Biotecnologia
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Autor/s de la URV: Pallejà, Albert; D Harrington, Eoghan; Bork, Peer
    Resum: Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.
    Any de publicació de la revista: 2008
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Data d'alta del registre: 2021-02-05
    Volum de revista: 9