Autor segons l'article: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montserrat; Ardevol, Anna
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Grau Bové, Maria Carmen / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
Paraules clau: Tumor Time factors Rats, wistar Rats Procyanidins Proanthocyanidins Grape seed proanthocyanidins Grape seed extract Glucagon/insulin Food intake Female Drug administration schedule Body weight Body composition Animals Aging Ageing Adiposity
Resum: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat mariacarmen.grau@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador de l'autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Data d'alta del registre: 2024-10-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6643/12/12/3647
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Nutrients. 12 (12): 1-12
Referència de l'ítem segons les normes APA: Grau-Bove, Carme; Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Mayte; Terra, Ximena; Pinent, Montser (2020). A ten-day grape seed procyanidin treatment prevents certain ageing processes in female rats over the long term. Nutrients, 12(12), 1-12. DOI: 10.3390/nu12123647
DOI de l'article: 10.3390/nu12123647
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV