Articles producció científica> Ciències Mèdiques Bàsiques

Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study

  • Dades identificatives

    Identificador: imarina:9187122
    Autors:
    Ribo-Coll, MargaritaCastro-Barquero, SaraLassale, CamilleSacanella, EmilioRos, EmilioToledo, EstefaniaSorli, Jose V.Diaz-Lopez, AndresLapetra, JoseMunoz-Bravo, CarlosAros, FernandoFiol, MiquelSerra-Majem, LluisPinto, XavierCastaner, OlgaFernandez-Lazaro, Cesar I.Portoles, OlgaBabio, NancyEstruch, RamonHernaez, Alvaro
    Resum:
    Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvencion con DIeta MEDiterranea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.
  • Altres:

    Autor segons l'article: Ribo-Coll, Margarita; Castro-Barquero, Sara; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefania; Sorli, Jose V.; Diaz-Lopez, Andres; Lapetra, Jose; Munoz-Bravo, Carlos; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Castaner, Olga; Fernandez-Lazaro, Cesar I.; Portoles, Olga; Babio, Nancy; Estruch, Ramon; Hernaez, Alvaro;
    Departament: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Babio Sánchez, Nancy Elvira / Díaz López, Andres
    Paraules clau: Vitamin k epoxide reductase inhibitors Statins Physical activity Mediterranean diet Glucose?lowering drugs Glucose-lowering drugs Fibrates Cardiac glycosides Antiplatelet drugs Antihypertensive drugs Antianginal drugs
    Resum: Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvencion con DIeta MEDiterranea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.
    Àrees temàtiques: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: andres.diaz@urv.cat nancy.babio@urv.cat
    Identificador de l'autor: 0000-0002-7500-5629 0000-0003-3527-5277
    Data d'alta del registre: 2024-07-27
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2076-3921/10/3/397
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Antioxidants. 10 (3): 1-15
    Referència de l'ítem segons les normes APA: Ribo-Coll, Margarita; Castro-Barquero, Sara; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefania; Sorli, Jose V.; Diaz-Lopez, Andres; (2021). Mediterranean Diet and Physical Activity Decrease the Initiation of Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A Cohort Study. Antioxidants, 10(3), 1-15. DOI: 10.3390/antiox10030397
    DOI de l'article: 10.3390/antiox10030397
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Vitamin k epoxide reductase inhibitors
    Statins
    Physical activity
    Mediterranean diet
    Glucose?lowering drugs
    Glucose-lowering drugs
    Fibrates
    Cardiac glycosides
    Antiplatelet drugs
    Antihypertensive drugs
    Antianginal drugs
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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