Autor segons l'article: Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, Juan; Trefler, Sandra; Vidaur, Loreto; Papiol, Elisabet; Socias, Lorenzo; Garcia-Vidal, Carolina; Correig, Eudald; Marin-Corral, Judith; Restrepo, Marcos, I; Nguyen-Van-Tam, Jonathan S.; Torres, Antoni;GETGAG Working Grp
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bodi Saera, Maria Amparo / Correig Fraga, Eudald / Gómez Alvarez, Josep / Rodríguez Oviedo, Alejandro Hugo / TREFLER CRESPO, SANDRA INES
Resum: Background: The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association between early oseltamivir treatment and ICU mortality in critically ill patients with influenza pneumonia.
Methods: This was an observational study of patients with influenza pneumonia admitted to 184 ICUs in Spain during 2009-2018. The primary outcome was to evaluate the association between early oseltamivir treatment and ICU mortality compared with later treatment. Secondary outcomes were to compare the duration of mechanical ventilation and ICU length of stay between the early and later oseltamivir treatment groups. To reduce biases related to observational studies, propensity score matching and a competing risk analysis were performed.
Results: During the study period, 2124 patients met the inclusion criteria. All patients had influenza pneumonia and received oseltamivir before ICU admission. Of these, 529 (24.9%) received early oseltamivir treatment. In the multivariate analysis, early treatment was associated with reduced ICU mortality (OR 0.69, 95% CI 0.51-0.95). After propensity score matching, early oseltamivir treatment was associated with improved survival rates in the Cox regression (hazard ratio 0.77, 95% CI 0.61-0.99) and competing risk (subdistribution hazard ratio 0.67, 95% CI 0.53-0.85) analyses. The ICU length of stay and duration of mechanical ventilation were shorter in patients receiving early treatment.
Conclusions: Early oseltamivir treatment is associated with improved survival rates in critically ill patients with influenza pneumonia, and may decrease ICU length of stay and mechanical ventilation duration.
Àrees temàtiques: Respiratory system Pulmonary and respiratory medicine
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josep.gomez@urv.cat eudald.correig@urv.cat alejandrohugo.rodriguez@urv.cat eudald.correig@urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
Identificador de l'autor: 0000-0002-0573-7621 0000-0001-8828-5984 0000-0001-7652-8379 0000-0001-7652-8379
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://openres.ersjournals.com/content/7/1/00888-2020.abstract
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Erj Open Research. 7 (1):
Referència de l'ítem segons les normes APA: Moreno, Gerard; Rodriguez, Alejandro; Sole-Violan, Jordi; Martin-Loeches, Ignacio; Diaz, Emili; Bodi, Maria; Reyes, Luis F.; Gomez, Josep; Guardiola, (2021). Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia. Erj Open Research, 7(1), -. DOI: 10.1183/23120541.00888-2020
DOI de l'article: 10.1183/23120541.00888-2020
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV