Autor segons l'article: Boughanem H; Canudas S; Hernandez‐alonso P; Becerra‐tomás N; Babio N; Salas‐salvadó J; Macias‐gonzalez M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Salas Salvadó, Jorge
Paraules clau: Vitamin d intake Systematic review Rectal-cancer Prospective Polymorphisms Phosphorus Newfoundland Micronutrients Meta‐analysis Meta-analysis Inhibition Incidence Dietary calcium Dairy-products Colorectal cancer Colon-cancer Case‐control Case-control Association
Resum: Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D– cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta‐analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE‐PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case‐control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q‐test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta‐analysis, comprising a total 47.540 cases and 70.567 controls in case‐control studies, and a total of 14.676 CRC‐incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case‐control studies, whereas a non‐significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta‐analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high‐quality prospective studies and clinical trials are war-ranted to confirm this association.
Àrees temàtiques: Oncology Medicina iii Cancer research
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: nerea.becerra@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador de l'autor: 0000-0002-4429-6507 0000-0003-2700-7459 0000-0003-3527-5277
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6694/13/11/2814
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Cancers. 13 (11):
Referència de l'ítem segons les normes APA: Boughanem H; Canudas S; Hernandez‐alonso P; Becerra‐tomás N; Babio N; Salas‐salvadó J; Macias‐gonzalez M (2021). Vitamin d intake and the risk of colorectal cancer: An updated meta‐analysis and systematic review of case‐control and prospective cohort studies. Cancers, 13(11), -. DOI: 10.3390/cancers13112814
DOI de l'article: 10.3390/cancers13112814
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV