Articles producció científica> Bioquímica i Biotecnologia

Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats

  • Dades identificatives

    Identificador: imarina:9218792
    Autors:
    Sierra-Cruz, MartaMiguens-Gomez, AlbaGrau-Bove, CarmeRodriguez-Gallego, EstherBlay, MaytePinent, MontserratArdevol, AnnaTerra, XimenaBeltran-Debon, Raul
    Resum:
    Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.
  • Altres:

    Autor segons l'article: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Grau-Bove, Carme; Rodriguez-Gallego, Esther; Blay, Mayte; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; Beltran-Debon, Raul
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
    Paraules clau: Weight loss Rats, wistar Rats Proanthocyanidins Obesity Metabolic syndrome Liver steatosis Insulin Grape seed proanthocyanidins Grape seed extract Glucagon Female Fatty liver Disease models, animal Diet-induced obesity Blood glucose Animals Ageing Adiposity resveratrol proanthocyanidins model metabolic syndrome liver steatosis liver intestinal inflammation insulin-resistance high-fat diet gut microbiota cafeteria diet body-weight ageing adiposity
    Resum: Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Identificador de l'autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
    Data d'alta del registre: 2024-10-19
    Volum de revista: 13
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/2072-6643/13/6/2059
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Nutrients. 13 (6): 2059-
    Referència de l'ítem segons les normes APA: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Grau-Bove, Carme; Rodriguez-Gallego, Esther; Blay, Mayte; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; B (2021). Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats. Nutrients, 13(6), 2059-. DOI: 10.3390/nu13062059
    DOI de l'article: 10.3390/nu13062059
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2021
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Weight loss
    Rats, wistar
    Rats
    Proanthocyanidins
    Obesity
    Metabolic syndrome
    Liver steatosis
    Insulin
    Grape seed proanthocyanidins
    Grape seed extract
    Glucagon
    Female
    Fatty liver
    Disease models, animal
    Diet-induced obesity
    Blood glucose
    Animals
    Ageing
    Adiposity
    resveratrol
    proanthocyanidins
    model
    metabolic syndrome
    liver steatosis
    liver
    intestinal inflammation
    insulin-resistance
    high-fat diet
    gut microbiota
    cafeteria diet
    body-weight
    ageing
    adiposity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar