Autor segons l'article: Romero-Aroca, Pedro; Navarro-Gil, Raul; Feliu, Albert; Valls, Aida; Moreno, Antonio; Baget-Bernaldiz, Marc
Departament: Enginyeria Informàtica i Matemàtiques
Autor/s de la URV: Baget Bernaldiz, Marc / Feliu Rovira, Albert / Moreno Ribas, Antonio / Navarro Gil, Raúl / Romero Aroca, Pedro / Valls Mateu, Aïda
Paraules clau: Systolic blood-pressure Severity of diabetic retinopathy Hba1c variability Hba(1c) variability Hba variability 1c Diabetic retinopathy Coefficient of variation of hba1c Coefficient of variation of hba 1c to-visit variability severity of diabetic retinopathy retinopathy progression prognostic-significance nephropathy microvascular complications microalbuminuria glucose variability follow-up diabetic retinopathy coefficient of variation of hba(1c)
Resum: Background: To measure the relationship between variability in HbA1c and microalbuminuria (MA) and diabetic retinopathy (DR) in the long term. Methods: A prospective case-series study, was conducted on 366 Type 1 Diabetes Mellitus patients with normoalbuminuria and without diabetic retinopathy at inclusion. The cohort was followed for a period of 12 years. The Cox survival analysis was used for the multivariate statistical study. The effect of variability in microangiopathy (retinopathy and nephropathy) was evaluated by calculating the standard deviation of HbA1c (SD-HbA1c ), the coefficient of variation of HbA1c (CV-HbA1c ), average real variability (ARV-HbA1c ) and variability irrespective of the mean (VIM-HbA1c ) adjusted for the other known variables. Results: A total of 106 patients developed diabetic retinopathy (29%) and 73 microalbuminuria (19.9%). Overt diabetic nephropathy, by our definition, affected only five patients (1.36%). Statistical results show that the current age, mean HbA1c, SD-HbA1c and ARV-HbA1c are significant in the development of diabetic retinopathy. Microalbuminuria was significant for current age, mean HbA1c, CV-HbA1c and ARV-HbA1c . Conclusions: By measuring the variability in HbA1c, we can use SD-HbA1c and ARV-HbA1c as possible targets for judging which patients are at risk of developing DR and MA, and CV-HbA1c as the target for severe DR.
Àrees temàtiques: Medicine, general & internal Internal medicine Clinical biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: marc.baget@urv.cat albert.feliu@urv.cat raul.navarrog@estudiants.urv.cat antonio.moreno@urv.cat pedro.romero@urv.cat aida.valls@urv.cat
Identificador de l'autor: 0000-0003-2970-205X 0000-0003-3945-2314 0000-0002-7061-8987 0000-0003-3616-7809
Data d'alta del registre: 2024-10-12
Volum de revista: 11
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Diagnostics. 11 (7): 1151-
Referència de l'ítem segons les normes APA: Romero-Aroca, Pedro; Navarro-Gil, Raul; Feliu, Albert; Valls, Aida; Moreno, Antonio; Baget-Bernaldiz, Marc (2021). The effect of hba1c variability as a risk measure for microangiopathy in type 1 diabetes mellitus. Diagnostics, 11(7), 1151-. DOI: 10.3390/diagnostics11071151
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications
Repositori URV