Autor segons l'article: Garcia-Escobar, E.; Valdes, S.; Soriguer, F.; Vendrell, J.; Urrutia-Etxebarria, I. M.; Maldonado-Araque, C.; Ortega, E.; Ocon, P.; Montanya, E.; Menendez, E.; Lago-Sampedro, A.; Gonzalez-Frutos, T.; Gomis, R.; Goday, A.; Garcia-Serrano, S.; Galan-Garcia, J. L.; Castell, C.; Bordiu, E.; Badia, R.; Aguilera-Venegas, G.; Girbes, J.; Gaztambide, S.; Delgado, E.; Chaves, F. J.; Castano, L.; Calle-Pascual, A.; Rojo-Martinez, G.; Franch-Nadal, J.;
Departament: Medicina i Cirurgia
Autor/s de la URV: Vendrell Ortega, Juan José
Paraules clau: Steatosis Population Nafld Management Insulin-resistance Homeostasis model assessment Glucose Disease
Resum: Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low (< 30), intermediate (30-60) and high (> 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: juanjose.vendrell@urv.cat
Identificador de l'autor: 0000-0002-6994-6115
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41598-021-95546-x
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Scientific Reports. 11 (1):
Referència de l'ítem segons les normes APA: Garcia-Escobar, E.; Valdes, S.; Soriguer, F.; Vendrell, J.; Urrutia-Etxebarria, I. M.; Maldonado-Araque, C.; Ortega, E.; Ocon, P.; Montanya, E.; Menen (2021). Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study. Scientific Reports, 11(1), -. DOI: 10.1038/s41598-021-95546-x
DOI de l'article: 10.1038/s41598-021-95546-x
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications