Autor segons l'article: Urpi-Sarda, Mireia; Casas, Rosa; Sacanella, Emilio; Corella, Dolores; Andres-Lacueva, Cristina; Llorach, Rafael; Garrabou, Gloria; Cardellach, Francesc; Sala-Vila, Aleix; Ros, Emilio; Ruiz-Canela, Miguel; Fito, Montserrat; Salas-Salvado, Jordi; Estruch, Ramon;
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Andres Lacueva, Cristina / Salas Salvadó, Jorge / Urpi Sarda, Mireia
Paraules clau: Style diet Nutrition Nlrp3 inflammasome Markers Low-grade inflammation Inflammation Immunity Gene expression Dysfunction Dietary pattern Cxcl5 Cholesterol Chemokines Cardiovascular diseases Atherosclerosis
Resum: The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1 beta, IL-6, IL-8, TNF-alpha, IFN-gamma, hs-CRP, MCP-1, MIP-1 beta, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1 beta, IL-6, IL-8, and TNF-alpha after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.
Àrees temàtiques: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: cristina.andres@urv.cat mireia.urpi@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-07-27
Volum de revista: 9
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2227-9059/9/8/862
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Biomedicines. 9 (8):
Referència de l'ítem segons les normes APA: Urpi-Sarda, Mireia; Casas, Rosa; Sacanella, Emilio; Corella, Dolores; Andres-Lacueva, Cristina; Llorach, Rafael; Garrabou, Gloria; Cardellach, Frances (2021). The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease. Biomedicines, 9(8), -. DOI: 10.3390/biomedicines9080862
DOI de l'article: 10.3390/biomedicines9080862
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications