Autor segons l'article: Diez, Cristina; Del Romero-Raposo, Jorge; Mican, Rafael; Lopez, Juan C.; Blanco, Jose R.; Calzado, Sonia; Samperiz, Gloria; Portilla, Joaquin; Garcia-Fraile, Lucio J.; Gutierrez, Felix; Gomez-Sirvent, Juan L.; Suarez-Garcia, Ines; Amador, Concha; Novella, Maria; Arribas, Jose R.; Moreno, Santiago; Gonzalez-Garcia, Juan; Jarrin, Inmaculada; Berenguer, Juan;CoRIS
Departament: Medicina i Cirurgia
Autor/s de la URV: Peraire Forner, José Joaquin
Paraules clau: Sars-cov-2 Hiv Covid-19 Coronavirus Cohort
Resum: Objectives We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/mu L. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.
Àrees temàtiques: Psicología Pharmacology (medical) Medicina ii Medicina i Infectious diseases Health policy Ciências biológicas iii Ciências biológicas i Biotecnología
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: joaquim.peraire@urv.cat
Identificador de l'autor: 0000-0001-7808-5479
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.13145
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Hiv Medicine. 22 (9): 867-876
Referència de l'ítem segons les normes APA: Diez, Cristina; Del Romero-Raposo, Jorge; Mican, Rafael; Lopez, Juan C.; Blanco, Jose R.; Calzado, Sonia; Samperiz, Gloria; Portilla, Joaquin; Garcia- (2021). COVID-19 in hospitalized HIV-positive and HIV-negative patients: A matched study. Hiv Medicine, 22(9), 867-876. DOI: 10.1111/hiv.13145
DOI de l'article: 10.1111/hiv.13145
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications