Articles producció científica> Medicina i Cirurgia

Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality

  • Dades identificatives

    Identificador: imarina:9230629
    Autors:
    Marquès MCorreig EIbarretxe DAnoro EAntonio Arroyo JJericó CBorrallo RMMiret MNäf SPardo APerea VPérez-Bernalte RRamírez-Montesinos RRoyuela MSoler CUrquizu-Padilla MZamora APedro-Botet JMasana LDomingo JL
    Resum:
    Background: Age, sex, race and comorbidities are insufficient to explain why some individuals remain asymptomatic after SARS-CoV-2 infection, while others die. In this sense, the increased risk caused by the long-term exposure to air pollution is being investigated to understand the high heterogeneity of the COVID-19 infection course. Objectives: We aimed to assess the underlying effect of long-term exposure to NO2 and PM10 on the severity and mortality of COVID-19. Methods: A retrospective observational study was conducted with 2112 patients suffering COVID-19 infection. We built two sets of multivariate predictive models to assess the relationship between the long-term exposure to NO2 and PM10 and COVID-19 outcome. First, the probability of either death or severe COVID-19 outcome was predicted as a function of all the clinical variables together with the pollutants exposure by means of two regularized logistic regressions. Subsequently, two regularized linear regressions were constructed to predict the percentage of dead or severe patients. Finally, odds ratios and effects estimates were calculated. Results: We found that the long-term exposure to PM10 is a more important variable than some already stated comorbidities (i.e.: COPD/Asthma, diabetes, obesity) in the prediction of COVID-19 severity and mortality. PM10 showed the highest effects estimates (1.65, 95% CI 1.32–2.06) on COVID-19 severity. For mortality, the highest effect estimates corresponded to age (3.59, 95% CI 2.94–4.40), followed by PM10 (2.37, 95% CI 1.71–3.32). Finally, an increase of 1 µg/m3 in PM10 concentration causes an increase of 3.06% (95% CI 1.11%-4.25%) of patients suffering COVID-19 as a severe disease and an increase of 2.68% (95% CI 0.53%-5.58%) of deaths. Discussion: These results demonst
  • Altres:

    Autor segons l'article: Marquès M; Correig E; Ibarretxe D; Anoro E; Antonio Arroyo J; Jericó C; Borrallo RM; Miret M; Näf S; Pardo A; Perea V; Pérez-Bernalte R; Ramírez-Montesinos R; Royuela M; Soler C; Urquizu-Padilla M; Zamora A; Pedro-Botet J; Masana L; Domingo JL
    Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Correig Fraga, Eudald / Domingo Roig, José Luis / Ibarretxe Gerediaga, Daiana / Marquès Bueno, Montserrat / Masana Marín, Luis
    Paraules clau: Pm10 Covid-19 severity Covid-19 mortality Covid-19 Air-pollution risks population pm10 covid-19 severity covid-19 mortality associations
    Resum: Background: Age, sex, race and comorbidities are insufficient to explain why some individuals remain asymptomatic after SARS-CoV-2 infection, while others die. In this sense, the increased risk caused by the long-term exposure to air pollution is being investigated to understand the high heterogeneity of the COVID-19 infection course. Objectives: We aimed to assess the underlying effect of long-term exposure to NO2 and PM10 on the severity and mortality of COVID-19. Methods: A retrospective observational study was conducted with 2112 patients suffering COVID-19 infection. We built two sets of multivariate predictive models to assess the relationship between the long-term exposure to NO2 and PM10 and COVID-19 outcome. First, the probability of either death or severe COVID-19 outcome was predicted as a function of all the clinical variables together with the pollutants exposure by means of two regularized logistic regressions. Subsequently, two regularized linear regressions were constructed to predict the percentage of dead or severe patients. Finally, odds ratios and effects estimates were calculated. Results: We found that the long-term exposure to PM10 is a more important variable than some already stated comorbidities (i.e.: COPD/Asthma, diabetes, obesity) in the prediction of COVID-19 severity and mortality. PM10 showed the highest effects estimates (1.65, 95% CI 1.32–2.06) on COVID-19 severity. For mortality, the highest effect estimates corresponded to age (3.59, 95% CI 2.94–4.40), followed by PM10 (2.37, 95% CI 1.71–3.32). Finally, an increase of 1 µg/m3 in PM10 concentration causes an increase of 3.06% (95% CI 1.11%-4.25%) of patients suffering COVID-19 as a severe disease and an increase of 2.68% (95% CI 0.53%-5.58%) of deaths. Discussion: These results demonstrate that long-term PM10 burdens above WHO guidelines exacerbate COVID-19 health outcomes. Hence, WHO guidelines, the air quality standard established by the Directive 2008/50/EU, and that of the US-EPA should be updated accordingly to protect human health.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Medicina iii Medicina ii Medicina i Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Engenharias iv Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: eudald.correig@urv.cat daiana.ibarretxe@urv.cat eudald.correig@urv.cat joseluis.domingo@urv.cat luis.masana@urv.cat
    Identificador de l'autor: 0000-0001-6647-9470 0000-0002-0789-4954
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0160412021005559?via%3Dihub
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Environment International. 158
    Referència de l'ítem segons les normes APA: Marquès M; Correig E; Ibarretxe D; Anoro E; Antonio Arroyo J; Jericó C; Borrallo RM; Miret M; Näf S; Pardo A; Perea V; Pérez-Bernalte R; Ramírez-Monte (2022). Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality. Environment International, 158(), -. DOI: 10.1016/j.envint.2021.106930
    DOI de l'article: 10.1016/j.envint.2021.106930
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Environmental Science (Miscellaneous),Environmental Sciences
    Pm10
    Covid-19 severity
    Covid-19 mortality
    Covid-19
    Air-pollution
    risks
    population
    pm10
    covid-19 severity
    covid-19 mortality
    associations
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Engenharias iv
    Engenharias ii
    Engenharias i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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