Autor segons l'article: Farre, X; Molina, R; Barteri, F; Timmers, PRHJ; Joshi, PK; Oliva, B; Acosta, S; Esteve-Altava, B; Navarro, A; Muntane, G
Departament: Medicina i Cirurgia
Autor/s de la URV: Muntané Medina, Gerard
Paraules clau: Wide association Reveals insights R package Protein Molecular signatures Model Maximum lifespan Human longevity Heritability Gwas Genetics Evolution Convergent evolution Comparative genomics Brain size Aging
Resum: The enormous mammal's lifespan variation is the result of each species' adaptations to their own biological trade-offs and ecological conditions. Comparative genomics have demonstrated that genomic factors underlying both, species lifespans and longevity of individuals, are in part shared across the tree of life. Here, we compared protein-coding regions across the mammalian phylogeny to detect individual amino acid (AA) changes shared by the most long-lived mammals and genes whose rates of protein evolution correlate with longevity. We discovered a total of 2,737 AA in 2,004 genes that distinguish long- and short-lived mammals, significantly more than expected by chance (P = 0.003). These genes belong to pathways involved in regulating lifespan, such as inflammatory response and hemostasis. Among them, a total 1,157 AA showed a significant association with maximum lifespan in a phylogenetic test. Interestingly, most of the detected AA positions do not vary in extant human populations (81.2%) or have allele frequencies below 1% (99.78%). Consequently, almost none of these putatively important variants could have been detected by genome-wide association studies. Additionally, we identified four more genes whose rate of protein evolution correlated with longevity in mammals. Crucially, SNPs located in the detected genes explain a larger fraction of human lifespan heritability than expected, successfully demonstrating for the first time that comparative genomics can be used to enhance interpretation of human genome-wide association studies. Finally, we show that the human longevity-associated proteins are significantly more stable than the orthologous proteins from short-lived mammals, strongly suggesting that general protein stability is linked to increased lifespan.
Àrees temàtiques: Química Molecular biology Medicina ii Medicina i Interdisciplinar Genetics & heredity Genetics General medicine Evolutionary biology Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biology, miscellaneous Biodiversidade Biochemistry & molecular biology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: gerard.muntane@urv.cat
Data d'alta del registre: 2024-07-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://academic.oup.com/mbe/article/38/11/4948/6326808?login=false
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecular Biology And Evolution. 38 (11): 4948-4961
Referència de l'ítem segons les normes APA: Farre, X; Molina, R; Barteri, F; Timmers, PRHJ; Joshi, PK; Oliva, B; Acosta, S; Esteve-Altava, B; Navarro, A; Muntane, G (2021). Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span. Molecular Biology And Evolution, 38(11), 4948-4961. DOI: 10.1093/molbev/msab219
DOI de l'article: 10.1093/molbev/msab219
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2021
Tipus de publicació: Journal Publications