Autor segons l'article: Deepika D; Rovira J; Sabuz Ó; Balaguer J; Schuhmacher M; Domingo JL; Kumar V
Departament: Enginyeria Química
Autor/s de la URV: Balaguer Trias, Jordina / Domingo Roig, José Luis / Kumar, Vikas / Rovira Solano, Joaquim / Sabuz Vidal, Oscar / Schuhmacher Ansuategui, Marta
Paraules clau: Translational in silico models Toxicokinetic model Systematic analysis Regulatory limits Pfos Pfoa Pfas Perfluorinated compounds Human biomonitoring Health effects Dietary toxicity translational in silico models toxicokinetic model systematic analysis substances regulatory limits pfos pfoa pfas perfluorooctanesulfonate life human biomonitoring health effects exposure
Resum: Perfluoroalkyl substances (PFAS), especially PFOS and PFOA, are two widely used synthetic chemicals that can impact human health based on evidence from animal and epidemiologic studies. In this paper, we have reviewed and summarized the influence of PFAS exposure on health, pointing the quality of evidence, and applied translational techniques to integrate evidence for PFAS policy making. This is the first review where highly referred articles on PFAS used for policymaking by several regulatory agencies were collected and evaluated based on the review guidelines developed by the US National Toxicology Program's Office of Health Assessment and Translation (OHAT) review guidelines. Several limitations were observed, including co-exposure to multiple chemicals and limited measurement of primary and secondary outcomes related to specific toxicity. However, data from all the studies provided a moderate to strong level of confidence for link between PFAS exposure and different adverse outcomes. Secondly, for translating the risk to humans, an in-silico model and scaling approach was utilized. Physiologically based pharmacokinetic model (PBPK) was used to calculate the human equivalent dose (HED) from two widely accepted studies and compared with tolerable daily intakes (TDIs) established by various regulatory agencies. Inter-species dose extrapolation was done to compare with human the relevance of dosing scenarios used in animals. Overall, a framework for translation of risk was proposed based on the conclusions of this review with the goal of improving policymaking. The current paper can improve the methodological protocols for PFAS experimental studies and encourage the utilization of in-silico models for translating risk.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: vikas.kumar@urv.cat oscar.sabuz@urv.cat joaquim.rovira@urv.cat marta.schuhmacher@urv.cat joseluis.domingo@urv.cat oscar.sabuz@urv.cat jordina.balaguer@estudiants.urv.cat jordina.balaguer@estudiants.urv.cat
Identificador de l'autor: 0000-0002-9795-5967 0000-0003-4399-6138 0000-0003-4381-2490 0000-0001-6647-9470 0000-0001-9001-207X 0000-0001-9001-207X
Data d'alta del registre: 2024-06-15
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0013935122000494?via%3Dihub
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Environmental Research. 208 112722-112722
Referència de l'ítem segons les normes APA: Deepika D; Rovira J; Sabuz Ó; Balaguer J; Schuhmacher M; Domingo JL; Kumar V (2022). Framework for risk assessment of PFAS utilizing experimental studies and in-silico models. Environmental Research, 208(), 112722-112722. DOI: 10.1016/j.envres.2022.112722
DOI de l'article: 10.1016/j.envres.2022.112722
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV