Articles producció científica> Medicina i Cirurgia

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

  • Dades identificatives

    Identificador: imarina:9249031
    Autors:
    Solomon, OHuen, KYousefi, PKüpers, LKGonzález, JRSuderman, MReese, SEPage, CMGruzieva, ORzehak, PGao, LBakulski, KMNovoloaca, AAllard, CPappa, ILlambrich, MVives, MJima, DDKvist, TBaccarelli, AWhite, CRezwan, FISharp, GCTindula, GBergström, AGrote, VDou, JFIsaevska, EMagnus, MCCorpeleijn, EPerron, PJaddoe, VWVNohr, EAMaitre, LForaster, MHoyo, CHåberg, SELahti, JDeMeo, DLZhang, HMKarmaus, WKull, IKoletzko, BFeinberg, JIGagliardi, LBouchard, LRamlau-Hansen, CHTiemeier, HSantorelli, GMaguire, RLCzamara, DLitonjua, AALanghendries, JPPlusquin, MLepeule, JBinder, EBVerduci, EDwyer, TCarracedo, AFerre, NEskenazi, BKogevinas, MNawrot, TSMunthe-Kaas, MCHerceg, ZRelton, CMelén, EGruszfeld, DBreton, CFallin, MDGhantous, ANystad, WHeude, BSnieder, HHivert, MFFelix, JFSorensen, TIABustamante, MMurphy, SKRaikkönen, KOken, EHolloway, JWArshad, SHLondon, SJHolland, N
    Resum:
    Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits. Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268). Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction. Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes.
  • Altres:

    Autor segons l'article: Solomon, O; Huen, K; Yousefi, P; Küpers, LK; González, JR; Suderman, M; Reese, SE; Page, CM; Gruzieva, O; Rzehak, P; Gao, L; Bakulski, KM; Novoloaca, A; Allard, C; Pappa, I; Llambrich, M; Vives, M; Jima, DD; Kvist, T; Baccarelli, A; White, C; Rezwan, FI; Sharp, GC; Tindula, G; Bergström, A; Grote, V; Dou, JF; Isaevska, E; Magnus, MC; Corpeleijn, E; Perron, P; Jaddoe, VWV; Nohr, EA; Maitre, L; Foraster, M; Hoyo, C; Håberg, SE; Lahti, J; DeMeo, DL; Zhang, HM; Karmaus, W; Kull, I; Koletzko, B; Feinberg, JI; Gagliardi, L; Bouchard, L; Ramlau-Hansen, CH; Tiemeier, H; Santorelli, G; Maguire, RL; Czamara, D; Litonjua, AA; Langhendries, JP; Plusquin, M; Lepeule, J; Binder, EB; Verduci, E; Dwyer, T; Carracedo, A; Ferre, N; Eskenazi, B; Kogevinas, M; Nawrot, TS; Munthe-Kaas, MC; Herceg, Z; Relton, C; Melén, E; Gruszfeld, D; Breton, C; Fallin, MD; Ghantous, A; Nystad, W; Heude, B; Snieder, H; Hivert, MF; Felix, JF; Sorensen, TIA; Bustamante, M; Murphy, SK; Raikkönen, K; Oken, E; Holloway, JW; Arshad, SH; London, SJ; Holland, N
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Ferre Pallas, Natalia / Llambrich Rodriguez, Maria
    Paraules clau: Sex characteristics Sex Pregnancy Male Infant, newborn Humans Gene Female Ewas Epigenomics Epigenome Epigenesis, genetic Dna methylation Cord blood Children Child Adolescent sex pregnancy package information gender expression ewas cord blood children
    Resum: Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits. Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268). Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction. Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes.
    Àrees temàtiques: Toxicology Medicina ii Medicina i Health, toxicology and mutagenesis Genetics & heredity Genetics General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biotechnology & applied microbiology Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: maria.llambrich@urv.cat maria.llambrich@urv.cat natalia.ferre@urv.cat
    Identificador de l'autor: 0000-0001-8418-0982 0000-0001-8418-0982 0000-0002-2838-1525
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S1383574222000059
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Mutation Research-Reviews In Mutation Research. 789 108415-
    Referència de l'ítem segons les normes APA: Solomon, O; Huen, K; Yousefi, P; Küpers, LK; González, JR; Suderman, M; Reese, SE; Page, CM; Gruzieva, O; Rzehak, P; Gao, L; Bakulski, KM; Novoloaca, (2022). Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutation Research-Reviews In Mutation Research, 789(), 108415-. DOI: 10.1016/j.mrrev.2022.108415
    DOI de l'article: 10.1016/j.mrrev.2022.108415
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biotechnology & Applied Microbiology,Genetics,Genetics & Heredity,Health, Toxicology and Mutagenesis,Toxicology
    Sex characteristics
    Sex
    Pregnancy
    Male
    Infant, newborn
    Humans
    Gene
    Female
    Ewas
    Epigenomics
    Epigenome
    Epigenesis, genetic
    Dna methylation
    Cord blood
    Children
    Child
    Adolescent
    sex
    pregnancy
    package
    information
    gender
    expression
    ewas
    cord blood
    children
    Toxicology
    Medicina ii
    Medicina i
    Health, toxicology and mutagenesis
    Genetics & heredity
    Genetics
    General medicine
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biotechnology & applied microbiology
    Biodiversidade
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