Autor segons l'article: Jalševac F; Terra X; Rodríguez-Gallego E; Beltran-Debón R; Blay MT; Pinent M; Ardévol A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: ARDÈVOL GRAU, ANA MARIA / BELTRÁN DEBÓN, RAÚL ALEJANDRO / PINENT ARMENGOL, MONTSERRAT / TERRA BARBADORA, XIMENA
Codi de projecte: Grant agreement No. 945413
Paraules clau: Tas2r39 antagonist Tas2r39 agonist Tas2r39 Respiratory system Gpcr Food intake Catechin Bitter taste
Resum: Over thousands of years of evolution, animals have developed many ways to protect themselves. One of the most protective ways to avoid disease is to prevent the absorption of harmful components. This protective function is a basic role of bitter taste receptors (TAS2Rs), a G protein-coupled receptor family, whose presence in extraoral tissues has intrigued many researchers. In humans, there are 25 TAS2Rs, and although we know a great deal about some of them, others are still shrouded in mystery. One in this latter category is bitter taste receptor 39 (TAS2R39). Besides the oral cavity, it has also been found in the gastrointestinal tract and the respiratory, nervous and reproductive systems. TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones. On the other hand, few antagonists for this receptor are available, since only some flavones have antagonistic properties (all of them detailed in the document). The primary role of TAS2R39 is to sense the bitter components of food and protect the organism from harmful compounds. There is also some indication that this bitter taste receptor regulates enterohormones and in turn, regulates food intake. In the respiratory system, it may be involved in the congestion process of allergic rhinitis and may stimulate inflammatory cytokines. However, more thorough research is needed to determine the precise role of TAS2R39 in these and other tissues.
Àrees temàtiques: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: ximena.terra@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat anna.ardevol@urv.cat
Identificador de l'autor: 0000-0003-1043-5844 0000-0001-9691-1906 0000-0003-3550-5378 0000-0003-0156-7538
Data d'alta del registre: 2022-04-16
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fendo.2022.854718/full
Programa de finançament: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
Referència a l'article segons font original: Frontiers In Endocrinology. 13
Referència de l'ítem segons les normes APA: Jalševac F; Terra X; Rodríguez-Gallego E; Beltran-Debón R; Blay MT; Pinent M; Ardévol A (2022). The Hidden One: What We Know About Bitter Taste Receptor 39. Frontiers In Endocrinology, 13(), -. DOI: 10.3389/fendo.2022.854718
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Acrònim: MFP-Plus
DOI de l'article: 10.3389/fendo.2022.854718
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Acció del programa de finançament: Martí i Franquès COFUND Doctoral Programme
Tipus de publicació: Journal Publications
Repositori URV