Articles producció científica> Bioquímica i Biotecnologia

The Hidden One: What We Know About Bitter Taste Receptor 39

  • Dades identificatives

    Identificador: imarina:9258968
    Autors:
    Jalsevac, FlorijanTerra, XimenaRodriguez-Gallego, EstherBeltran-Debon, RaulBlay, Maria TeresaPinent, MontserratArdevol, Anna
    Resum:
    Over thousands of years of evolution, animals have developed many ways to protect themselves. One of the most protective ways to avoid disease is to prevent the absorption of harmful components. This protective function is a basic role of bitter taste receptors (TAS2Rs), a G protein-coupled receptor family, whose presence in extraoral tissues has intrigued many researchers. In humans, there are 25 TAS2Rs, and although we know a great deal about some of them, others are still shrouded in mystery. One in this latter category is bitter taste receptor 39 (TAS2R39). Besides the oral cavity, it has also been found in the gastrointestinal tract and the respiratory, nervous and reproductive systems. TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones. On the other hand, few antagonists for this receptor are available, since only some flavones have antagonistic properties (all of them detailed in the document). The primary role of TAS2R39 is to sense the bitter components of food and protect the organism from harmful compounds. There is also some indication that this bitter taste receptor regulates enterohormones and in turn, regulates food intake. In the respiratory system, it may be involved in the congestion process of allergic rhinitis and may stimulate inflammatory cytokines. However, more thorough research is needed to determine the precise role of TAS2R39 in these and other tissues.
  • Altres:

    Autor segons l'article: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Jalsevac, Florijan / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
    Codi de projecte: Grant agreement No. 945413
    Paraules clau: Taste buds Taste Tas2r39 antagonist Tas2r39 agonist Tas2r39 Respiratory system Receptors, g-protein-coupled Gpcr Gastrointestinal tract Food intake Catechin Bitter taste Animals
    Resum: Over thousands of years of evolution, animals have developed many ways to protect themselves. One of the most protective ways to avoid disease is to prevent the absorption of harmful components. This protective function is a basic role of bitter taste receptors (TAS2Rs), a G protein-coupled receptor family, whose presence in extraoral tissues has intrigued many researchers. In humans, there are 25 TAS2Rs, and although we know a great deal about some of them, others are still shrouded in mystery. One in this latter category is bitter taste receptor 39 (TAS2R39). Besides the oral cavity, it has also been found in the gastrointestinal tract and the respiratory, nervous and reproductive systems. TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones. On the other hand, few antagonists for this receptor are available, since only some flavones have antagonistic properties (all of them detailed in the document). The primary role of TAS2R39 is to sense the bitter components of food and protect the organism from harmful compounds. There is also some indication that this bitter taste receptor regulates enterohormones and in turn, regulates food intake. In the respiratory system, it may be involved in the congestion process of allergic rhinitis and may stimulate inflammatory cytokines. However, more thorough research is needed to determine the precise role of TAS2R39 in these and other tissues.
    Àrees temàtiques: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Identificador de l'autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
    Data d'alta del registre: 2024-10-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.frontiersin.org/articles/10.3389/fendo.2022.854718/full
    Programa de finançament: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Frontiers In Endocrinology. 13 854718-
    Referència de l'ítem segons les normes APA: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna (2022). The Hidden One: What We Know About Bitter Taste Receptor 39. Frontiers In Endocrinology, 13(), 854718-. DOI: 10.3389/fendo.2022.854718
    Acrònim: MFP-Plus
    DOI de l'article: 10.3389/fendo.2022.854718
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022
    Acció del programa de finançament: Martí i Franquès COFUND Doctoral Programme
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Taste buds
    Taste
    Tas2r39 antagonist
    Tas2r39 agonist
    Tas2r39
    Respiratory system
    Receptors, g-protein-coupled
    Gpcr
    Gastrointestinal tract
    Food intake
    Catechin
    Bitter taste
    Animals
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
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