Articles producció científicaBioquímica i Biotecnologia

Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study

  • Dades identificatives

    Identificador:  imarina:9262493
    Handle: https://hdl.handle.net/20.500.11797/imarina9262493
    Autors:  Atzeni, Alessandro; Bastiaanssen, Thomaz F S; Cryan, John F; Tinahones, Francisco J; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Gomez-Perez, Ana M; Torres-Collado, Laura; Coltell, Oscar; Castaner, Olga; Bullo, Monica; Salas-Salvado, Jordi
    Resum:
    Objective: An altered gut microbiota has been associated with insulin resistance, a metabolic dysfunction consisting of cellular insulin signaling impairment. The aim of the present study is to determine the taxonomic and functional fecal microbiota signatures associated with HOMA-IR index in a population with high cardiovascular risk. Methods: A total of 279 non-diabetic individuals (55–75 years aged) with overweight/obesity and metabolic syndrome were stratified according to tertiles of HOMA-IR index. Blood biochemical parameters, anthropometric measurements and fecal samples were collected at baseline. Fecal microbial DNA extraction, 16S amplicon sequencing and bioinformatics analysis were performed. Results: Desulfovibrio, Odoribacter and Oscillospiraceae UCG-002 were negatively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to amino acid degradation. Butyricicoccus, Erysipelotrichaceae UCG-003, Faecalibacterium were positively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to saccharide degradation. These bacteria contribute differentially to the gut metabolic modules, being the degree of contribution dependent on insulin resistance. Both taxa and gut metabolic modules negatively associated to HOMA-IR index were linked to mechanisms involving sulfate reducing bacteria, improvement of intestinal gluconeogenesis and production of acetate. Furthermore, both taxa and gut metabolic modules positively associated to HOMA-IR index were linked to production and mechanisms of action of butyrate. Conclusions: Specific taxonomic and functional fecal microbiota signatures associated with insulin resistance were identified in a non

  • Altres:

    Autor segons l'article: Atzeni, Alessandro; Bastiaanssen, Thomaz F S; Cryan, John F; Tinahones, Francisco J; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Gomez-Perez, Ana M; Torres-Collado, Laura; Coltell, Oscar; Castaner, Olga; Bullo, Monica; Salas-Salvado, Jordi
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Atzeni, Alessandro / Bulló Bonet, Mònica / Martínez Rodríguez, María Ángeles / Salas Salvadó, Jorge
    Paraules clau: Overweight; Obesity; Microbiota; Mediterranean diet adherence; Insulin resistance; Insulin resisitance; Humans; Homa-ir; Gut metabolic modules; Good health and well-being; Feces; Fecal microbiota; Aged; 16s sequencing; obesity; modulation; metabolic syndrome; insulin resisitance; impact; homa-ir; gut microbiota; gut metabolic modules; glucose; butyrate; 16s sequencing
    Resum: Objective: An altered gut microbiota has been associated with insulin resistance, a metabolic dysfunction consisting of cellular insulin signaling impairment. The aim of the present study is to determine the taxonomic and functional fecal microbiota signatures associated with HOMA-IR index in a population with high cardiovascular risk. Methods: A total of 279 non-diabetic individuals (55–75 years aged) with overweight/obesity and metabolic syndrome were stratified according to tertiles of HOMA-IR index. Blood biochemical parameters, anthropometric measurements and fecal samples were collected at baseline. Fecal microbial DNA extraction, 16S amplicon sequencing and bioinformatics analysis were performed. Results: Desulfovibrio, Odoribacter and Oscillospiraceae UCG-002 were negatively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to amino acid degradation. Butyricicoccus, Erysipelotrichaceae UCG-003, Faecalibacterium were positively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to saccharide degradation. These bacteria contribute differentially to the gut metabolic modules, being the degree of contribution dependent on insulin resistance. Both taxa and gut metabolic modules negatively associated to HOMA-IR index were linked to mechanisms involving sulfate reducing bacteria, improvement of intestinal gluconeogenesis and production of acetate. Furthermore, both taxa and gut metabolic modules positively associated to HOMA-IR index were linked to production and mechanisms of action of butyrate. Conclusions: Specific taxonomic and functional fecal microbiota signatures associated with insulin resistance were identified in a non-diabetic population with overweight/obesity at high cardiovascular risk. These findings suggest that tailoring therapies based on specific fecal microbiota profiles could be a potential strategy to improve insulin sensitivity.
    Àrees temàtiques: Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Farmacia; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Ciências biológicas ii; Ciências biológicas i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: mangeles.martinez@urv.cat; a.atzeni86@gmail.com; monica.bullo@urv.cat; jordi.salas@urv.cat
    Data d'alta del registre: 2026-03-02
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097279/
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Frontiers In Endocrinology. 13 804455-
    Referència de l'ítem segons les normes APA: Atzeni, Alessandro; Bastiaanssen, Thomaz F S; Cryan, John F; Tinahones, Francisco J; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; (2022). Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study. Frontiers In Endocrinology, 13(), 804455-. DOI: 10.3389/fendo.2022.804455
    DOI de l'article: 10.3389/fendo.2022.804455
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2022-04-28
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Overweight
    Obesity
    Microbiota
    Mediterranean diet adherence
    Insulin resistance
    Insulin resisitance
    Humans
    Homa-ir
    Gut metabolic modules
    Good health and well-being
    Feces
    Fecal microbiota
    Aged
    16s sequencing
    obesity
    modulation
    metabolic syndrome
    insulin resisitance
    impact
    homa-ir
    gut microbiota
    gut metabolic modules
    glucose
    butyrate
    16s sequencing
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i

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