Autor segons l'article: Segura-Alabart, Natalia; Serratosa, Francesc; Gomez, Sergio; Fernandez, Alberto
Departament: Enginyeria Informàtica i Matemàtiques Enginyeria Química
Autor/s de la URV: Fernández Sabater, Alberto / Gómez Jiménez, Sergio / Segura Alabart, Natàlia / Serratosa Casanelles, Francesc d'Assís
Paraules clau: Upgma Tie in proximity Str Ssr Microsatellite repeats Microsatellite marker Genetic diversity Dendrogram Computational biology Cluster analysis upgma tie in proximity str ssr simple sequences l. dendrogram
Resum: Agglomerative hierarchical clustering has become a common tool for the analysis and visualization of data, thus being present in a large amount of scientific research and predating all areas of bioinformatics and computational biology. In this work, we focus on a critical problem, the nonuniqueness of the clustering when there are tied distances, for which several solutions exist but are not implemented in most hierarchical clustering packages. We analyze the magnitude of this problem in one particular setting: the clustering of microsatellite markers using the Unweighted Pair-Group Method with Arithmetic Mean. To do so, we have calculated the fraction of publications at the Scopus database in which more than one hierarchical clustering is possible, showing that about 46% of the articles are affected. Additionally, to show the problem from a practical point of view, we selected two opposite examples of articles that have multiple solutions: one with two possible dendrograms, and the other with more than 2.5 million different possible hierarchical clusterings.© The Author(s) 2022. Published by Oxford University Press.
Àrees temàtiques: Molecular biology Medicine (all) Mathematical & computational biology Information systems Ciências biológicas i Ciência da computação Biotechnology & applied microbiology Biochemical research methods
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: natalia.segura@urv.cat natalia.segura@urv.cat natalia.segura@urv.cat alberto.fernandez@urv.cat sergio.gomez@urv.cat francesc.serratosa@urv.cat
Identificador de l'autor: 0000-0002-1241-1646 0000-0003-1820-0062 0000-0001-6112-5913
Data d'alta del registre: 2024-10-26
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://academic.oup.com/bib/article/23/5/bbac312/6652780
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Briefings In Bioinformatics. 23 (5): bbac312-bbac312
Referència de l'ítem segons les normes APA: Segura-Alabart, Natalia; Serratosa, Francesc; Gomez, Sergio; Fernandez, Alberto (2022). Nonunique UPGMA clusterings of microsatellite markers. Briefings In Bioinformatics, 23(5), bbac312-bbac312. DOI: https://doi.org/10.1093/bib/bbac312
DOI de l'article: https://doi.org/10.1093/bib/bbac312
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications