Autor segons l'article: Marhuenda-Munoz, Maria; Dominguez-Lopez, Ines; Laveriano-Santos, Emily P.; Parilli-Moser, Isabella; Razquin, Cristina; Ruiz-Canela, Miguel; Basterra-Gortari, Francisco Javier; Corella, Dolores; Salas-Salvado, Jordi; Fito, Montserrat; Lapetra, Jose; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Gomez-Gracia, Enrique; Ros, Emilio; Estruch, Ramon; Lamuela-Raventos, Rosa M.;
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Urinary microbial phenolic metabolites Total polyphenols Quantification Predimed study Phytochemicals Olive Mediterranean diet Mass spectrometry Liquid chromatography Health Cardiovascular Blood-pressure Bioactive compounds Anthocyanins Acid
Resum: The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
Àrees temàtiques: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2076-3921/11/8/1540
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antioxidants. 11 (8):
Referència de l'ítem segons les normes APA: Marhuenda-Munoz, Maria; Dominguez-Lopez, Ines; Laveriano-Santos, Emily P.; Parilli-Moser, Isabella; Razquin, Cristina; Ruiz-Canela, Miguel; Basterra-G (2022). One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study. Antioxidants, 11(8), -. DOI: 10.3390/antiox11081540
DOI de l'article: 10.3390/antiox11081540
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV