Articles producció científica> Enginyeria Química

Binding of calix[4]pyrroles to pyridine N-oxides probed with surface plasmon resonance

  • Dades identificatives

    Identificador: imarina:9282521
    Autors:
    Adriaenssens LAcero Sánchez JLBarril XO'Sullivan CKBallester P
    Resum:
    Using a commercial instrument that integrates microfluidics with surface plasmon resonance (SPR) detection, we thermodynamically and kinetically characterise the interactions of water-soluble calix[4]pyrroles with surface-immobilized guests derived from pyridine N-oxide. This technique provides detailed information in real time and shows that, while thermodynamically similar, the binding process occurring with the surface-immobilised guests is kinetically very different to that in solution. Two different binding processes can be distinguished for the surface-immobilised guests. Both complexation processes provide 1:1 complexes with thermodynamic stabilities that are similar to each other and to the 1:1 complex formed in solution. However, the kinetic stabilities of the complexes formed with the surface anchored ligands are significantly higher. These observations are rationalized on the basis of the effects exerted by the dextran matrix employed for the ligand's immobilisation on the small molecule complexes that are formed. This journal is © the Partner Organisations 2014.
  • Altres:

    Autor segons l'article: Adriaenssens L; Acero Sánchez JL; Barril X; O'Sullivan CK; Ballester P
    Departament: Enginyeria Química
    Autor/s de la URV: ACERO SÁNCHEZ, JOSEP LLUÍS / O'SULLIVAN, CIARA KATHLEEN
    Paraules clau: Pyridine n-oxides
    Resum: Using a commercial instrument that integrates microfluidics with surface plasmon resonance (SPR) detection, we thermodynamically and kinetically characterise the interactions of water-soluble calix[4]pyrroles with surface-immobilized guests derived from pyridine N-oxide. This technique provides detailed information in real time and shows that, while thermodynamically similar, the binding process occurring with the surface-immobilised guests is kinetically very different to that in solution. Two different binding processes can be distinguished for the surface-immobilised guests. Both complexation processes provide 1:1 complexes with thermodynamic stabilities that are similar to each other and to the 1:1 complex formed in solution. However, the kinetic stabilities of the complexes formed with the surface anchored ligands are significantly higher. These observations are rationalized on the basis of the effects exerted by the dextran matrix employed for the ligand's immobilisation on the small molecule complexes that are formed. This journal is © the Partner Organisations 2014.
    Àrees temàtiques: Astronomia / física Chemistry (all) Chemistry (miscellaneous) Chemistry, multidisciplinary Ciências biológicas i Ciências biológicas iii Farmacia General chemistry Interdisciplinar Materiais Química
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: ciara.osullivan@urv.cat
    Identificador de l'autor: 0000-0002-0965-4655 0000-0003-2603-2230
    Data d'alta del registre: 2022-10-15
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc01745e
    Referència a l'article segons font original: Chemical Science. 5 (11): 4210-4215
    Referència de l'ítem segons les normes APA: Adriaenssens L; Acero Sánchez JL; Barril X; O'Sullivan CK; Ballester P (2014). Binding of calix[4]pyrroles to pyridine N-oxides probed with surface plasmon resonance. Chemical Science, 5(11), 4210-4215. DOI: 10.1039/c4sc01745e
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1039/c4sc01745e
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Pyridine n-oxides
    Astronomia / física
    Chemistry (all)
    Chemistry (miscellaneous)
    Chemistry, multidisciplinary
    Ciências biológicas i
    Ciências biológicas iii
    Farmacia
    General chemistry
    Interdisciplinar
    Materiais
    Química
  • Documents:

  • Cerca a google

    Search to google scholar