Autor segons l'article: Gayathri, R; Abirami, K; Kalpana, N; Manasa, VS; Sudha, V; Shobana, S; Jeevan, RG; Kavitha, V; Parkavi, K; Anjana, RM; Unnikrishnan, R; Gokulakrishnan, K; Beatrice, DA; Krishnaswamy, K; Pradeepa, R; Mattes, RD; Salas-Salvadó, J; Willett, W; Mohan, V
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Serum lipid Overweight and obesity Insulin sensitivity Insulin resistance Cardiovascular risk-factors Asian–indian Almond type-2 serum lipid resistance profiles prevention overweight and obesity nuts insulin sensitivity insulin resistance glucose dose-response diet body-weight asian-indian
Resum: Background: Asian Indians have an increased susceptibility to type 2 diabetes and premature coronary artery disease. Nuts, like almonds, are rich in unsaturated fat and micronutrients with known health benefits. Objectives: This study aimed to assess the efficacy of almonds for reduction of insulin resistance and improving lipid profile in overweight Asian Indian adults. Methods: This parallel-arm, randomized, controlled trial was conducted in Chennai, India on 400 participants aged 25–65 years with a body mass index ≥ 23 kg/m2. The intervention group received 43 g of almonds/day for 12 weeks, while the control group was advised to consume a customary diet but to avoid nuts. Anthropometric, clinical, and dietary data were assessed at periodic intervals. Glucose tolerance, serum insulin, glycated hemoglobin, C-peptide and lipid profile were assessed at baseline and end of the study. Insulin resistance (homeostasis assessment model-HOMA IR) and oral insulin disposition index (DIo) were calculated. Results: A total of 352 participants completed the study. Significant improvement was seen in DIo [mean (95% CI) = + 0.7 mmol/L (0.1, 1.3); p = 0.03], HOMA IR (−0.4 (−0.7, −0.04; p = 0.03) and total cholesterol (−5.4 mg/dl (−10.2, −0.6); p = 0.03) in the intervention group compared to the control group. Incremental area under the curve (IAUC) and mean amplitude of glycemic excursion (MAGE) assessed using continuous glucose monitoring systems were also significantly lower in the intervention group. Dietary 24-h recalls showed a higher significant reduction in carbohydrate and increase in mono unsaturated fatty acid (MUFA) and polyunsaturated fatty acids (PUFA) intake in the intervention group compared to the control group. Conclusion: Daily consumption of almonds increased the intake of MUFA with decrease in carbohydrate calories and decreases insulin resistance, improves insulin sensitivity and lowers serum cholesterol in Asian Indians with overweight/obesity. These effects in the long run could aid in reducing the risk of diabetes and other cardiometabolic disease.
Àrees temàtiques: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Front Nutr. 9
Referència de l'ítem segons les normes APA: Gayathri, R; Abirami, K; Kalpana, N; Manasa, VS; Sudha, V; Shobana, S; Jeevan, RG; Kavitha, V; Parkavi, K; Anjana, RM; Unnikrishnan, R; Gokulakrishnan (2023). Effect of almond consumption on insulin sensitivity and serum lipids among Asian Indian adults with overweight and obesity– A randomized controlled trial. Front Nutr, 9(), -. DOI: 10.3389/fnut.2022.1055923
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV