Autor segons l'article: Villanueva-Carmona, Teresa; Cedo, Lidia; Madeira, Ana; Ceperuelo-Mallafre, Victoria; Rodriguez-Pena, M -Mar; Nunez-Roa, Catalina; Maymo-Masip, Elsa; Repolles-de-Dalmau, Maria; Badia, Joan; Keiran, Noelia; Mirasierra, Mercedes; Pimenta-Lopes, Carolina; Sabadell-Basallote, Joan; Bosch, Ramon; Caubet, Laura; Escola-Gil, Joan Carles; Fernandez-Real, Jose-Manuel; Vilarrasa, Nuria; Ventura, Francesc; Vallejo, Mario; Vendrell, Joan; Fernandez-Veledo, Sonia
Departament: Bioquímica i Biotecnologia Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/s de la URV: Badia Aparicio, José María / Bosch Príncep, Ramon / CEDÓ GINÉ, LÍDIA / Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Maymo Masip, Elsa / RODRIGUEZ PEÑA, MARIA DEL MAR / Vendrell Ortega, Juan José / Villanueva Carmona, Teresa
Paraules clau: Sucnr1 Succinates Succinate Obesity Mice, knockout Mice Metabolite Metabolism Leptin Humans Gpr91 protein, mouse Gpcr Energy metabolism Circadian clocks Circadian clock Animals Adipose tissue Adipocytes Adipocyte Activated protein-kinase succinate stem-cells plasma leptin ob gene glucose-uptake gene-expression food-intake bone-formation ampk activation
Resum: Adipose tissue modulates energy homeostasis by secreting leptin, but little is known about the factors governing leptin production. We show that succinate, long perceived as a mediator of immune response and lipolysis, controls leptin expression via its receptor SUCNR1. Adipocyte-specific deletion of Sucnr1 influences metabolic health according to nutritional status. Adipocyte Sucnr1 deficiency impairs leptin response to feeding, whereas oral succinate mimics nutrient-related leptin dynamics via SUCNR1. SUCNR1 activation controls leptin expression via the circadian clock in an AMPK/JNK-C/EBPα-dependent manner. Although the anti-lipolytic role of SUCNR1 prevails in obesity, its function as a regulator of leptin signaling contributes to the metabolically favorable phenotype in adipocyte-specific Sucnr1 knockout mice under standard dietary conditions. Obesity-associated hyperleptinemia in humans is linked to SUCNR1 overexpression in adipocytes, which emerges as the major predictor of adipose tissue leptin expression. Our study establishes the succinate/SUCNR1 axis as a metabolite-sensing pathway mediating nutrient-related leptin dynamics to control whole-body homeostasis.Copyright © 2023 Elsevier Inc. All rights reserved.
Àrees temàtiques: Physiology Odontología Molecular biology Medicina ii Medicina i Interdisciplinar General medicine Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cell biology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: ramon.bosch@urv.cat josepmaria.badia@urv.cat elsa.maymo@urv.cat victoria.ceperuelo@urv.cat ramon.bosch@urv.cat josepmaria.badia@urv.cat josepmaria.badia@urv.cat teresa.villanueva@urv.cat sonia.fernandez@urv.cat jvortega@iispv.cat
Identificador de l'autor: 0000-0002-9133-3120 0000-0002-4460-9761 0000-0003-2906-3788 0000-0002-6994-6115
Data d'alta del registre: 2025-02-01
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Cell Metabolism. 35 (4): 601-619.e10
Referència de l'ítem segons les normes APA: Villanueva-Carmona, Teresa; Cedo, Lidia; Madeira, Ana; Ceperuelo-Mallafre, Victoria; Rodriguez-Pena, M -Mar; Nunez-Roa, Catalina; Maymo-Masip, Elsa; R (2023). SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression. Cell Metabolism, 35(4), 601-619.e10. DOI: 10.1016/j.cmet.2023.03.004
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV