Autor segons l'article: Lejeune, M; Reverte, L; Gallardo, N; Sauras, E; Bosch, R; Mata, D; Roso, A; Petit, A; Peg, V; Riu, F; Garcia-Fontgivell, J; Relea, F; Vieites, B; de la Cruz-merino, L; Arenas, M; Rodriguez, V; Galera, J; Korzynska, A; Plancoulaine, B; Alvaro, T; Lopez, C
Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/s de la URV: Arenas Prat, Meritxell / Galera Ortega, Juana / Lejeune, Marylène Marie / Lopez Pablo, Carlos
Paraules clau: Tumor microenvironment Triple-negative breast cancer Pathological response Neoadjuvant chemotherapy Biomarkers tumor microenvironment pathological response neoadjuvant chemotherapy biomarkers
Resum: Triple-negative breast cancer (TNBC) is particularly challenging due to the weak or absent response to therapeutics and its poor prognosis. The effectiveness of neoadjuvant chemotherapy (NAC) response is strongly influenced by changes in elements of the tumor microenvironment (TME). This work aimed to characterize the residual TME composition in 96 TNBC patients using immunohistochemistry and in situ hybridization techniques and evaluate its prognostic implications for partial responders vs. non-responders. Compared with non-responders, partial responders containing higher levels of CD83+ mature dendritic cells, FOXP3+ regulatory T cells, and IL-15 expression but lower CD138+ cell concentration exhibited better OS and RFS. However, along with tumor diameter and positive nodal status at diagnosis, matrix metalloproteinase-9 (MMP-9) expression in the residual TME was identified as an independent factor associated with the impaired response to NAC. This study yields new insights into the key components of the residual tumor bed, such as MMP-9, which is strictly associated with the lack of a pathological response to NAC. This knowledge might help early identification of TNBC patients less likely to respond to NAC and allow the establishment of new therapeutic targets.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: juana.galera@urv.cat carlos.lopez@urv.cat marylenemarie.lejeune@urv.cat meritxell.arenas@urv.cat
Identificador de l'autor: 0000-0003-1248-3065 0000-0001-8441-9404 0000-0003-0815-2570
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/24/14/11297
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 24 (14):
Referència de l'ítem segons les normes APA: Lejeune, M; Reverte, L; Gallardo, N; Sauras, E; Bosch, R; Mata, D; Roso, A; Petit, A; Peg, V; Riu, F; Garcia-Fontgivell, J; Relea, F; Vieites, B; de l (2023). Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients. International Journal Of Molecular Sciences, 24(14), -. DOI: 10.3390/ijms241411297
DOI de l'article: 10.3390/ijms241411297
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications