Articles producció científica> Medicina i Cirurgia

Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue

  • Dades identificatives

    Identificador: imarina:9326331
    Autors:
    Binetti, JessicaReal, MonicaRenzulli, MarcelaBertran, LaiaRiesco, DavidPerpinan, CarlesMohedano, AlbaSegundo, Rosa SanOrtiz, MartaPorras, Jose AntonioPineda, Daniela RosannaAuguet, Teresa
    Resum:
    Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to analyze the impact of a supervised exercise program on the clinical evolution of LC with fatigue patients and to identify whether certain circulating biomarkers could predict the response to rehabilitation. The rehabilitation treatment response was analyzed in 14 women diagnosed with LC and fatigue, based on the changes in the 6 min walk test and Borg/Fatigue Impact scales. Patients who showed improvement in the meters walked were considered responders to the therapy. A total of 65% of patients responded to the exercise program, with an improvement in the meters walked and in oxygen saturation, with stability in the percentage of meters walked. Participants with obesity and those double-vaccinated against SARS-CoV-2 presented a lower degree of fatigue. LC patients presented a favorable response to a supervised exercise program. Differences in creatinine and protein levels were observed between rehabilitation therapy responders and nonresponders. A good state of protein nutrition was related to a better rehabilitation response. The results are promising regarding possible predictive biomarkers of rehabilitation response, such as creatinine.
  • Altres:

    Autor segons l'article: Binetti, Jessica; Real, Monica; Renzulli, Marcela; Bertran, Laia; Riesco, David; Perpinan, Carles; Mohedano, Alba; Segundo, Rosa San; Ortiz, Marta; Porras, Jose Antonio; Pineda, Daniela Rosanna; Auguet, Teresa
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Perpiñan Auguet, Carles / Porras Ledantes, Jose Antonio / Real Álvarez, Monica Maria / Riesco Acevedo, David Gerardo / San Segundo Mozo, Rosa María
    Paraules clau: Sars-cov-2 Post-acute covid-19 syndrome Physical rehabilitation Long covid Humans Female Fatigue syndrome, chronic Creatinine Covid-19 Chronic fatigue Biomarkers sars-cov-2 physical rehabilitation chronic fatigue biomarkers
    Resum: Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to analyze the impact of a supervised exercise program on the clinical evolution of LC with fatigue patients and to identify whether certain circulating biomarkers could predict the response to rehabilitation. The rehabilitation treatment response was analyzed in 14 women diagnosed with LC and fatigue, based on the changes in the 6 min walk test and Borg/Fatigue Impact scales. Patients who showed improvement in the meters walked were considered responders to the therapy. A total of 65% of patients responded to the exercise program, with an improvement in the meters walked and in oxygen saturation, with stability in the percentage of meters walked. Participants with obesity and those double-vaccinated against SARS-CoV-2 presented a lower degree of fatigue. LC patients presented a favorable response to a supervised exercise program. Differences in creatinine and protein levels were observed between rehabilitation therapy responders and nonresponders. A good state of protein nutrition was related to a better rehabilitation response. The results are promising regarding possible predictive biomarkers of rehabilitation response, such as creatinine.
    Àrees temàtiques: Zootecnia / recursos pesqueiros Virology Saúde coletiva Química Medicina veterinaria Medicina ii Medicina i Interdisciplinar Infectious diseases Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: davidgerardo.riesco@urv.cat monicamaria.real@urv.cat jessicaangela.binetti@urv.cat carles.perpinan@urv.cat joseantonio.porras@urv.cat rosamaria.sansegundo@urv.cat jessicaangela.binetti@urv.cat carles.perpinan@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat mariateresa.auguet@urv.cat
    Identificador de l'autor: 0000-0001-6418-1822 0000-0001-7420-2914 0000-0001-9052-1368 0000-0001-9052-1368 0000-0003-0396-6428
    Data d'alta del registre: 2024-09-21
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.mdpi.com/1999-4915/15/7/1452
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Viruses-Basel. 15 (7): 1452-
    Referència de l'ítem segons les normes APA: Binetti, Jessica; Real, Monica; Renzulli, Marcela; Bertran, Laia; Riesco, David; Perpinan, Carles; Mohedano, Alba; Segundo, Rosa San; Ortiz, Marta; Po (2023). Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue. Viruses-Basel, 15(7), 1452-. DOI: 10.3390/v15071452
    DOI de l'article: 10.3390/v15071452
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Infectious Diseases,Virology
    Sars-cov-2
    Post-acute covid-19 syndrome
    Physical rehabilitation
    Long covid
    Humans
    Female
    Fatigue syndrome, chronic
    Creatinine
    Covid-19
    Chronic fatigue
    Biomarkers
    sars-cov-2
    physical rehabilitation
    chronic fatigue
    biomarkers
    Zootecnia / recursos pesqueiros
    Virology
    Saúde coletiva
    Química
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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