Autor segons l'article: Yadav, TC; Bachhuka, A
Departament: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: Bachhuka, Akash / Yadav, Tara Chand
Paraules clau: Gold nanoparticles tio2 nanotubes resistant bacteria protein-adsorption nlrp3 inflammasome in-vitro giant-cells electrospun fibers biological responses adsorbed proteins
Resum: Biomaterials are omnipresent in today's healthcare services and are employed in various applications, including implants, sensors, healthcare accessories, and drug delivery systems. Unfavorable host immunological responses frequently jeopardize the efficacy of biomaterials. As a result, surface modification has received much attention in controlling inflammatory responses since it helps camouflage the biomaterial from the host immune system, influencing the foreign body response (FBR) from protein adsorption to fibrous capsule formation. Surfaces with controlled nanotopography and chemistry, among other surface modification methodologies, have effectively altered the immune response to biomaterials. However, the field is still in its early stages, with only a few studies showing a synergistic effect of surface chemistry and nanotopography on inflammatory and wound healing pathways. Therefore, this review will concentrate on the individual and synergistic effects of surface chemistry and nanotopography on FBR modulation and the molecular processes known to modulate these responses. This review will also provide insights into crucial research gaps and advancements in various tactics for modulating FBR, opening new paths for future research. This will further aid in improving our understanding of the immune response to biomaterials, developing advanced surface modification techniques, designing immunomodulatory biomaterials, and translating discoveries into clinical applications.
Àrees temàtiques: Química Odontología Medicine (miscellaneous) Medicina ii Materials science, biomaterials Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General medicine General materials science General chemistry Farmacia Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry (miscellaneous) Chemistry (all) Biotecnología Biomedical engineering Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: tarachand.yadav@urv.cat akash.bachhuka@urv.cat
Identificador de l'autor: 0000-0003-1253-8126
Data d'alta del registre: 2024-01-13
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb01040f
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Materials Chemistry b. 11 (33): 7834-
Referència de l'ítem segons les normes APA: Yadav, TC; Bachhuka, A (2023). Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications. Journal Of Materials Chemistry b, 11(33), 7834-. DOI: 10.1039/d3tb01040f
DOI de l'article: 10.1039/d3tb01040f
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV