Autor segons l'article: Mora, I; Pérez-Santamaria, A; Tortajada-Pérez, J; Vázquez-Manrique, RP; Arola, L; Puiggròs, F
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Arola Ferrer, Luis Maria
Paraules clau: Structured lipids Pufa Polyunsaturated fatty-acids Physical decline Oxidative stress Omega-3 Nematode Healthspan Docosahexaenoic acid Daf-16/foxo Cognitive decline C. elegans Antioxidant Aging triglycerides structured lipids resistance pufa physical decline phospholipids oxidative stress omega-3 neurotransmission nematode modulation longevity life-span healthspan foxo elegans docosahexaenoic acid daf-16 cognitive decline caenorhabditis-elegans c antioxidant
Resum: The human lifespan has increased over the past century; however, healthspans have not kept up with this trend, especially cognitive health. Among nutrients for brain function maintenance, long-chain omega-3 polyunsaturated fatty acids (ω-3 LCPUFA): DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) must be highlighted, particularly structured forms of EPA and DHA which were developed to improve bioavailability and bioactivity in comparison with conventional ω-3 supplements. This study aims to elucidate the effect of a structured triglyceride form of DHA (DHA-TG) on the healthspan of aged C. elegans. Using a thrashing assay, the nematodes were monitored at 4, 8, and 12 days of adulthood, and DHA-TG improved its motility at every age without affecting lifespan. In addition, the treatment promoted antioxidant capacity by enhancing the activity and expression of SOD (superoxide dismutase) in the nematodes. Lastly, as the effect of DHA-TG was lost in the DAF-16 mutant strain, it might be hypothesized that the effects of DHA need DAF-16/FOXO as an intermediary. In brief, DHA-TG exerted a healthspan-promoting effect resulting in both enhanced physical fitness and increased antioxidant defense in aged C. elegans. For the first time, an improvement in locomotive function in aged wild-type nematodes is described following DHA-TG treatment.
Àrees temàtiques: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: lluis.arola@urv.cat
Identificador de l'autor: 0000-0003-2767-1974
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2073-4409/12/15/1932
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Cells. 12 (15):
Referència de l'ítem segons les normes APA: Mora, I; Pérez-Santamaria, A; Tortajada-Pérez, J; Vázquez-Manrique, RP; Arola, L; Puiggròs, F (2023). Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans. Cells, 12(15), -. DOI: 10.3390/cells12151932
DOI de l'article: 10.3390/cells12151932
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV