Autor segons l'article: Moreno, F; Méndez, L; Raner, A; Miralles-Pérez, B; Romeu, M; Ramos-Romero, S; Torres, JL; Medina, I
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Miralles Pérez, Bernat / Romeu Ferran, Marta
Paraules clau: Protein carbonylation Prediabetes Oxidative stress Omega-3 fish oil High-fat and high-sucrose diet Cerebral cortex proteins protein carbonylation prediabetes polyphenols phospholipids parkinsons-disease oxidative stress model mice inflammation high-fat and high-sucrose diet docosahexaenoic acid cerebral cortex brain
Resum: High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats. To achieve this goal, the study identified and quantified the carbonylated proteins and lipid peroxidation products in the cortex, and correlated them with biometrical, biochemical and other redox status parameters. Results demonstrated that the obesogenic diet selectively increased oxidative damage of specific proteins that participate in fundamental pathways for brain function, i.e. energy production, glucose metabolism and neurotransmission. This study also evaluated the antioxidant properties of fish oil to counteract diet-induced brain oxidative damage. Fish oil supplementation demonstrated a stronger capacity to modulate carbonylated proteome in the brain cortex. Data indicated that fish oils did not just decrease carbonylation of proteins affected by the obesogenic diet, but also decreased the oxidative damage of other proteins participating in the same metabolic functions, reinforcing the beneficial effect of the supplement on those pathways. The results could help contribute to the development of successful nutritional-based interventions to prevent cognitive decline and promote brain health.
Àrees temàtiques: Saúde coletiva Química Pharmacology & pharmacy Pharmacology Odontología Medicine, research & experimental Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iii Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: bernat.miralles@urv.cat marta.romeu@urv.cat bernat.miralles@urv.cat
Identificador de l'autor: 0000-0003-1294-7069 0000-0002-2131-1858 0000-0003-1294-7069
Data d'alta del registre: 2023-12-17
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0753332223015068?via%3Dihub
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Biomedicine & Pharmacotherapy. 168
Referència de l'ítem segons les normes APA: Moreno, F; Méndez, L; Raner, A; Miralles-Pérez, B; Romeu, M; Ramos-Romero, S; Torres, JL; Medina, I (2023). Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex. Biomedicine & Pharmacotherapy, 168(), -. DOI: 10.1016/j.biopha.2023.115708
DOI de l'article: 10.1016/j.biopha.2023.115708
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV