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Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review

  • Dades identificatives

    Identificador: imarina:9331073
    Autors:
    Mateo, DavidMarques, MontseDomingo, Jose LTorrente, Margarita
    Resum:
    Dementia is one of today's greatest public health challenges. Its high socio-economic impact and difficulties in diagnosis and treatment are of increasing concern to an aging world population. In recent years, the study of the relationship between gut microbiota and different neurocognitive disorders has gained a considerable interest. Several studies have reported associations between gut microbiota dysbiosis and some types of dementia. Probiotics have been suggested to restore dysbiosis and to improve neurocognitive symptomatology in these dementias. Based on these previous findings, the available scientific evidence on the gut microbiota in humans affected by the most prevalent dementias, as well as the probiotic trials conducted in these patients in recent years, have been here reviewed. Decreased concentrations of short-chain fatty acids (SCFA) and other bacterial metabolites appear to play a major role in the onset of neurocognitive symptoms in Alzheimer disease (AD) and Parkinson disease dementia (PDD). Increased abundance of proinflammatory taxa could be closely related to the more severe clinical symptoms in both, as well as in Lewy Bodies dementia. Important lack of information was noted in Frontotemporal dementia behavioral variant. Moreover, geographical differences in the composition of the gut microbiota have been reported in AD. Some potential beneficial effects of probiotics in AD and PDD have been reported. However, due to the controversial results further investigations are clearly necessary.© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
  • Altres:

    Autor segons l'article: Mateo, David; Marques, Montse; Domingo, Jose L; Torrente, Margarita
    Departament: Psicologia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Domingo Roig, José Luis / Marquès Bueno, Montserrat / Mateo García, David / Torrente Torné, Margarita
    Paraules clau: Probiotics Parkinson disease dementia Parkinson disease Humans Gut microbiota Gastrointestinal microbiome Dysbiosis Dementia Chain fatty-acids Alzheimer disease Aged probiotics parkinsons-disease parkinson disease dementia gut microbiota dementia brain
    Resum: Dementia is one of today's greatest public health challenges. Its high socio-economic impact and difficulties in diagnosis and treatment are of increasing concern to an aging world population. In recent years, the study of the relationship between gut microbiota and different neurocognitive disorders has gained a considerable interest. Several studies have reported associations between gut microbiota dysbiosis and some types of dementia. Probiotics have been suggested to restore dysbiosis and to improve neurocognitive symptomatology in these dementias. Based on these previous findings, the available scientific evidence on the gut microbiota in humans affected by the most prevalent dementias, as well as the probiotic trials conducted in these patients in recent years, have been here reviewed. Decreased concentrations of short-chain fatty acids (SCFA) and other bacterial metabolites appear to play a major role in the onset of neurocognitive symptoms in Alzheimer disease (AD) and Parkinson disease dementia (PDD). Increased abundance of proinflammatory taxa could be closely related to the more severe clinical symptoms in both, as well as in Lewy Bodies dementia. Important lack of information was noted in Frontotemporal dementia behavioral variant. Moreover, geographical differences in the composition of the gut microbiota have been reported in AD. Some potential beneficial effects of probiotics in AD and PDD have been reported. However, due to the controversial results further investigations are clearly necessary.© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
    Àrees temàtiques: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Genetics (clinical) Genetics & heredity General medicine Ensino Ciências biológicas ii Ciências biológicas i Cellular and molecular neuroscience Biotecnología Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: david.mateo@urv.cat joseluis.domingo@urv.cat margarita.torrente@urv.cat
    Identificador de l'autor: 0000-0001-6647-9470 0000-0002-8901-6345
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32959
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 195 (2): e32959-e32959
    Referència de l'ítem segons les normes APA: Mateo, David; Marques, Montse; Domingo, Jose L; Torrente, Margarita (2024). Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review. American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 195(2), e32959-e32959. DOI: 10.1002/ajmg.b.32959
    DOI de l'article: 10.1002/ajmg.b.32959
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cellular and Molecular Neuroscience,Genetics & Heredity,Genetics (Clinical),Psychiatry,Psychiatry and Mental Health
    Probiotics
    Parkinson disease dementia
    Parkinson disease
    Humans
    Gut microbiota
    Gastrointestinal microbiome
    Dysbiosis
    Dementia
    Chain fatty-acids
    Alzheimer disease
    Aged
    probiotics
    parkinsons-disease
    parkinson disease dementia
    gut microbiota
    dementia
    brain
    Saúde coletiva
    Psychiatry and mental health
    Psychiatry
    Psicología
    Medicina ii
    Medicina i
    Genetics (clinical)
    Genetics & heredity
    General medicine
    Ensino
    Ciências biológicas ii
    Ciências biológicas i
    Cellular and molecular neuroscience
    Biotecnología
    Biodiversidade
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