Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Similarity network fusion to identify phenotypes of small-for-gestational-age fetuses

  • Dades identificatives

    Identificador: imarina:9331197
    Autors:
    Miranda, JPaules, CNoell, GYoussef, LPaternina-Caicedo, ACrovetto, FCañellas, NGarcia-Martín, MLAmigó, NEixarch, EFaner, RFigueras, FSimos, RCrispi, FGratacós, E
    Resum:
    Fetal growth restriction (FGR) affects 5-10% of pregnancies, is the largest contributor to fetal death, and can have long-term consequences for the child. Implementation of a standard clinical classification system is hampered by the multiphenotypic spectrum of small fetuses with substantial differences in perinatal risks. Machine learning and multiomics data can potentially revolutionize clinical decision-making in FGR by identifying new phenotypes. Herein, we describe a cluster analysis of FGR based on an unbiased machine-learning method. Our results confirm the existence of two subtypes of human FGR with distinct molecular and clinical features based on multiomic analysis. In addition, we demonstrated that clusters generated by machine learning significantly outperform single data subtype analysis and biologically support the current clinical classification in predicting adverse maternal and neonatal outcomes. Our approach can aid in the refinement of clinical classification systems for FGR supported by molecular and clinical signatures.
  • Altres:

    Autor segons l'article: Miranda, J; Paules, C; Noell, G; Youssef, L; Paternina-Caicedo, A; Crovetto, F; Cañellas, N; Garcia-Martín, ML; Amigó, N; Eixarch, E; Faner, R; Figueras, F; Simos, R; Crispi, F; Gratacós, E
    Departament: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/s de la URV: Cañellas Alberich, Nicolau
    Paraules clau: Term Pregnancy Preeclampsia Nmr-spectroscopy Natriuretic peptide Management Fetal-growth restriction Early-onset Doppler Consequences
    Resum: Fetal growth restriction (FGR) affects 5-10% of pregnancies, is the largest contributor to fetal death, and can have long-term consequences for the child. Implementation of a standard clinical classification system is hampered by the multiphenotypic spectrum of small fetuses with substantial differences in perinatal risks. Machine learning and multiomics data can potentially revolutionize clinical decision-making in FGR by identifying new phenotypes. Herein, we describe a cluster analysis of FGR based on an unbiased machine-learning method. Our results confirm the existence of two subtypes of human FGR with distinct molecular and clinical features based on multiomic analysis. In addition, we demonstrated that clusters generated by machine learning significantly outperform single data subtype analysis and biologically support the current clinical classification in predicting adverse maternal and neonatal outcomes. Our approach can aid in the refinement of clinical classification systems for FGR supported by molecular and clinical signatures.
    Àrees temàtiques: Multidisciplinary sciences Multidisciplinary
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: nicolau.canyellas@urv.cat
    Identificador de l'autor: 0000-0003-4856-8132
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.sciencedirect.com/science/article/pii/S2589004223016978
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Iscience. 26 (9):
    Referència de l'ítem segons les normes APA: Miranda, J; Paules, C; Noell, G; Youssef, L; Paternina-Caicedo, A; Crovetto, F; Cañellas, N; Garcia-Martín, ML; Amigó, N; Eixarch, E; Faner, R; Figuer (2023). Similarity network fusion to identify phenotypes of small-for-gestational-age fetuses. Iscience, 26(9), -. DOI: 10.1016/j.isci.2023.107620
    DOI de l'article: 10.1016/j.isci.2023.107620
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Multidisciplinary,Multidisciplinary Sciences
    Term
    Pregnancy
    Preeclampsia
    Nmr-spectroscopy
    Natriuretic peptide
    Management
    Fetal-growth restriction
    Early-onset
    Doppler
    Consequences
    Multidisciplinary sciences
    Multidisciplinary
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