Articles producció científica> Medicina i Cirurgia

A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass

  • Dades identificatives

    Identificador: imarina:9331758
    Handle: https://hdl.handle.net/20.500.11797/imarina9331758
    Autors:
    Hernández-Montoliu LRodríguez-Peña MMPuig RAstiarraga BGuerrero-Pérez FVirgili NLópez-Urdiales ROsorio JMonseny RLazzara CSobrino LPérez-Maraver MPérez-Prieto MPellitero SFernández-Veledo SVendrell JVilarrasa N
    Resum:
    Objective: To determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement. Materials and methods: Prospective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota. Results: Thirteen patients aged 52.6 ± 6.5 years, BMI 39.3 ± 1.4 kg/m2, HbA1c 7.62 ± 1.5% were evaluated. After mRYGB, zonulin decreased and an increase in AUC after MTT was observed for GLP-1 (pre 9371 ± 5973 vs post 15788 ± 8021 pM, P<0.05), GLP-2 (pre 732 ± 182 vs post 1190 ± 447 ng/ml, P<0.001) and C- peptide, as well as after LT. Species belonging to Streptococaceae, Akkermansiacea, Rickenellaceae, Sutterellaceae, Enterobacteriaceae, Oscillospiraceae, Veillonellaceae, Enterobacterales_uc, and Fusobacteriaceae families increased after intervention and correlated positively with AUC of GLP-1 and GLP-2, and negatively with glucose, HbA1c, triglycerides and adiposity markers. Clostridium perfringens and Roseburia sp. 40_7 behaved similarly. In contrast, some species belonging to Lachnospiraceae, Erysipelotricaceae, and Rumnicocaceae families decreased and showed opposite correlations. Higher initial C-peptide was the only predictor for T2D remission, which was achieved in 69% of patients. Conclusions: Patients with obesity and T2D submitted to mRYGB s

  • Altres:

    Autor segons l'article: Hernández-Montoliu L; Rodríguez-Peña MM; Puig R; Astiarraga B; Guerrero-Pérez F; Virgili N; López-Urdiales R; Osorio J; Monseny R; Lazzara C; Sobrino L; Pérez-Maraver M; Pérez-Prieto M; Pellitero S; Fernández-Veledo S; Vendrell J; Vilarrasa N
    Departament: Medicina i Cirurgia Bioquímica i Biotecnologia
    Autor/s de la URV: Domínguez Porfirio, Brenno / Fernandez Veledo, Sonia / RODRIGUEZ PEÑA, MARIA DEL MAR / Vendrell Ortega, Juan José
    Paraules clau: Type 2 diabetes remission Sleeve gastrectomy Severe obesity Microbiota Incretin Bariatric surgery type 2 diabetes remission severe obesity remission obesity microbiota mellitus mechanisms marker inflammation barrier function bariatric surgery
    Resum: Objective: To determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement. Materials and methods: Prospective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota. Results: Thirteen patients aged 52.6 ± 6.5 years, BMI 39.3 ± 1.4 kg/m2, HbA1c 7.62 ± 1.5% were evaluated. After mRYGB, zonulin decreased and an increase in AUC after MTT was observed for GLP-1 (pre 9371 ± 5973 vs post 15788 ± 8021 pM, P<0.05), GLP-2 (pre 732 ± 182 vs post 1190 ± 447 ng/ml, P<0.001) and C- peptide, as well as after LT. Species belonging to Streptococaceae, Akkermansiacea, Rickenellaceae, Sutterellaceae, Enterobacteriaceae, Oscillospiraceae, Veillonellaceae, Enterobacterales_uc, and Fusobacteriaceae families increased after intervention and correlated positively with AUC of GLP-1 and GLP-2, and negatively with glucose, HbA1c, triglycerides and adiposity markers. Clostridium perfringens and Roseburia sp. 40_7 behaved similarly. In contrast, some species belonging to Lachnospiraceae, Erysipelotricaceae, and Rumnicocaceae families decreased and showed opposite correlations. Higher initial C-peptide was the only predictor for T2D remission, which was achieved in 69% of patients. Conclusions: Patients with obesity and T2D submitted to mRYGB show an enhanced incretin response, a reduced gut permeability and a metabolic improvement, associated with a specific microbiota signature.
    Àrees temàtiques: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: brenno.dominguez@urv.cat sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
    Identificador de l'autor: 0000-0003-2216-8974 0000-0003-2906-3788 0000-0002-6994-6115
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.frontiersin.org/articles/10.3389/fendo.2023.1181744/full
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Frontiers In Endocrinology. 14
    Referència de l'ítem segons les normes APA: Hernández-Montoliu L; Rodríguez-Peña MM; Puig R; Astiarraga B; Guerrero-Pérez F; Virgili N; López-Urdiales R; Osorio J; Monseny R; Lazzara C; Sobrino (2023). A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass. Frontiers In Endocrinology, 14(), -. DOI: 10.3389/fendo.2023.1181744
    DOI de l'article: 10.3389/fendo.2023.1181744
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Type 2 diabetes remission
    Sleeve gastrectomy
    Severe obesity
    Microbiota
    Incretin
    Bariatric surgery
    type 2 diabetes remission
    severe obesity
    remission
    obesity
    microbiota
    mellitus
    mechanisms
    marker
    inflammation
    barrier function
    bariatric surgery
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i

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