Articles producció científica> Medicina i Cirurgia

Exposure to air pollution as an environmental determinant of how Sjögren’s disease is expressed at diagnosis

  • Dades identificatives

    Identificador: imarina:9351824
    Handle: https://hdl.handle.net/20.500.11797/imarina9351824
    Autors:
    Brito-Zerón PFlores-Chávez ANg WFHorváth IFRasmussen APriori RBaldini CArmagan BÖzkiziltaş BPraprotnik SSuzuki YQuartuccio LHernandez-Molina GAbacar KBartoloni ERischmueller MReis-De FOTrevisani VFMJurcut CFugmann CCarubbi FHofauer BValim VPasoto SGRetamozo SAtzeni FFonseca-Aizpuru ELópez-Dupla MGiacomelli RNakamura HAkasbi MThompson KSzántó AFarris ADVilla MBombardieri SKilic LTufan APirkmajer KPFujisawa YDe Vita SInanc NRamos-Casals M
    Resum:
    Objective To analyse how the potential exposure to air pollutants can influence the key components at the time of diagnosis of Sjögren’s phenotype (epidemiological profile, sicca symptoms, and systemic disease). Methods For the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Air pollution indexes per country were defined according to the OECD (1990-2021), including emission data of nitrogen and sulphur oxides (NO/SO), particulate matter (PM2.5 and 1.0), carbon monoxide (CO) and volatile organic compounds (VOC) calculated per unit of GDP, kg per 1000 USD. Results The results of the chi-square tests of independence for each air pollutant with the frequency of dry eyes at diagnosis showed that, except for one, all variables exhibited p-values <0.0001. The most pronounced disparities emerged in the dry eye prevalence among individuals inhabiting countries with the highest NO/SO exposure, a surge of 4.61 percentage points compared to other countries, followed by CO (3.59 points), non-methane (3.32 points), PM2.5 (3.30 points), and PM1.0 (1.60 points) exposures. Concerning dry mouth, individuals residing in countries with worse NO/SO exposures exhibited a heightened frequency of dry mouth by 2.05 percentage points (p<0.0001), followed by non-methane exposure (1.21 percentage points increase, p=0.007). Individuals inhabiting countries with the worst NO/SO, CO, and PM2.5 pollution levels had a higher mean global ESSDAI score than those in lower-risk nations (all p-values <0.0001). When systemic disease was stratified according to DAS into low, moderate, and high systemic activity levels, a heightened proportion of individuals manifesti

  • Altres:

    Autor segons l'article: Brito-Zerón P; Flores-Chávez A; Ng WF; Horváth IF; Rasmussen A; Priori R; Baldini C; Armagan B; Özkiziltaş B; Praprotnik S; Suzuki Y; Quartuccio L; Hernandez-Molina G; Abacar K; Bartoloni E; Rischmueller M; Reis-De FO; Trevisani VFM; Jurcut C; Fugmann C; Carubbi F; Hofauer B; Valim V; Pasoto SG; Retamozo S; Atzeni F; Fonseca-Aizpuru E; López-Dupla M; Giacomelli R; Nakamura H; Akasbi M; Thompson K; Szántó A; Farris AD; Villa M; Bombardieri S; Kilic L; Tufan A; Pirkmajer KP; Fujisawa Y; De Vita S; Inanc N; Ramos-Casals M
    Departament: Medicina i Cirurgia
    Autor/s de la URV: López Dupla, Jesús Miguel
    Paraules clau: Systemic Sjogren’s syndrome Essdai Environment Dryness Air pollution
    Resum: Objective To analyse how the potential exposure to air pollutants can influence the key components at the time of diagnosis of Sjögren’s phenotype (epidemiological profile, sicca symptoms, and systemic disease). Methods For the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Air pollution indexes per country were defined according to the OECD (1990-2021), including emission data of nitrogen and sulphur oxides (NO/SO), particulate matter (PM2.5 and 1.0), carbon monoxide (CO) and volatile organic compounds (VOC) calculated per unit of GDP, kg per 1000 USD. Results The results of the chi-square tests of independence for each air pollutant with the frequency of dry eyes at diagnosis showed that, except for one, all variables exhibited p-values <0.0001. The most pronounced disparities emerged in the dry eye prevalence among individuals inhabiting countries with the highest NO/SO exposure, a surge of 4.61 percentage points compared to other countries, followed by CO (3.59 points), non-methane (3.32 points), PM2.5 (3.30 points), and PM1.0 (1.60 points) exposures. Concerning dry mouth, individuals residing in countries with worse NO/SO exposures exhibited a heightened frequency of dry mouth by 2.05 percentage points (p<0.0001), followed by non-methane exposure (1.21 percentage points increase, p=0.007). Individuals inhabiting countries with the worst NO/SO, CO, and PM2.5 pollution levels had a higher mean global ESSDAI score than those in lower-risk nations (all p-values <0.0001). When systemic disease was stratified according to DAS into low, moderate, and high systemic activity levels, a heightened proportion of individuals manifesting moderate/severe systemic activity was observed in countries with worse exposures to NO/SO, CO, and PM2.5 pollutant levels. Conclusion For the first time, we suggest that pollution levels could influence how SjD appears at diagnosis in a large international cohort of patients. The most notable relationships were found between symptoms (dryness and general body symptoms) and NO/SO, CO, and PM2.5 levels.
    Àrees temàtiques: Saúde coletiva Rheumatology Odontología Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Immunology and allergy Immunology General medicine Farmacia Engenharias ii Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Administração, ciências contábeis e turismo
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: jesusmiguel.lopez@urv.cat
    Identificador de l'autor: 0000-0002-9141-2523
    Data d'alta del registre: 2025-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Referència a l'article segons font original: Clinical And Experimental Rheumatology. 41 (12): 2448-2457
    Referència de l'ítem segons les normes APA: Brito-Zerón P; Flores-Chávez A; Ng WF; Horváth IF; Rasmussen A; Priori R; Baldini C; Armagan B; Özkiziltaş B; Praprotnik S; Suzuki Y; Quartuccio L; He (2023). Exposure to air pollution as an environmental determinant of how Sjögren’s disease is expressed at diagnosis. Clinical And Experimental Rheumatology, 41(12), 2448-2457
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Immunology,Immunology and Allergy,Rheumatology
    Systemic
    Sjogren’s syndrome
    Essdai
    Environment
    Dryness
    Air pollution
    Saúde coletiva
    Rheumatology
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Immunology and allergy
    Immunology
    General medicine
    Farmacia
    Engenharias ii
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Administração, ciências contábeis e turismo

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