Articles producció científica> Medicina i Cirurgia

Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes

  • Dades identificatives

    Identificador: imarina:9365691
    Autors:
    Guardiola MRehues PAmigó NArrieta FBotana MGimeno-Orna JAGirona JMartínez-Montoro JIOrtega EPérez-Pérez ASánchez-Margalet VPedro-Botet JRibalta J
    Resum:
    The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between dyslipidaemia and atherosclerosis in T2DM is complex, and our contention is that a deeper understanding of lipoprotein composition and functionality, the vehicle that delivers cholesterol to the artery, will provide insight for improving our understanding of the hidden cardiovascular risk of diabetes. This narrative review covers three levels of complexity in lipoprotein characterization: 1-the information provided by routine clinical biochemistry, 2-advanced nuclear magnetic resonance (NMR)-based lipoprotein profiling and 3-the identification of minor components or physical properties of lipoproteins that can help explain arterial accumulation in individuals with normal LDLc levels, which is typically the case in individuals with T2DM. This document highlights the importance of incorporating these three layers of lipoprotein-related information into population-based studies on ASCVD in T2DM. Such an attempt should inevitably run in parallel with biotechnological solutions that allow large-scale determination of these sets of methodologically diverse parameters.© 2024 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
  • Altres:

    Autor segons l'article: Guardiola M; Rehues P; Amigó N; Arrieta F; Botana M; Gimeno-Orna JA; Girona J; Martínez-Montoro JI; Ortega E; Pérez-Pérez A; Sánchez-Margalet V; Pedro-Botet J; Ribalta J
    Departament: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/s de la URV: Girona Tell, Josefa / Guardiola Guionnet, Montserrat / Rehues Masip, Pere / Ribalta Vives, Josep
    Paraules clau: Nmr Lps Lipoprotein Diabetes Cardiovascular risk Apoc‐iii Apoc-iii
    Resum: The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between dyslipidaemia and atherosclerosis in T2DM is complex, and our contention is that a deeper understanding of lipoprotein composition and functionality, the vehicle that delivers cholesterol to the artery, will provide insight for improving our understanding of the hidden cardiovascular risk of diabetes. This narrative review covers three levels of complexity in lipoprotein characterization: 1-the information provided by routine clinical biochemistry, 2-advanced nuclear magnetic resonance (NMR)-based lipoprotein profiling and 3-the identification of minor components or physical properties of lipoproteins that can help explain arterial accumulation in individuals with normal LDLc levels, which is typically the case in individuals with T2DM. This document highlights the importance of incorporating these three layers of lipoprotein-related information into population-based studies on ASCVD in T2DM. Such an attempt should inevitably run in parallel with biotechnological solutions that allow large-scale determination of these sets of methodologically diverse parameters.© 2024 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
    Àrees temàtiques: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: pere.rehues@urv.cat josefa.girona@urv.cat pere.rehues@urv.cat josefa.girona@urv.cat montse.guardiola@urv.cat josep.ribalta@urv.cat
    Identificador de l'autor: 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-9696-7384 0000-0002-8879-4719
    Data d'alta del registre: 2024-09-21
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://onlinelibrary.wiley.com/doi/10.1111/eci.14214
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: European Journal Of Clinical Investigation. e14214-e14214
    Referència de l'ítem segons les normes APA: Guardiola M; Rehues P; Amigó N; Arrieta F; Botana M; Gimeno-Orna JA; Girona J; Martínez-Montoro JI; Ortega E; Pérez-Pérez A; Sánchez-Margalet V; Pedro (2024). Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes. European Journal Of Clinical Investigation, (), e14214-e14214. DOI: 10.1111/eci.14214
    DOI de l'article: 10.1111/eci.14214
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Clinical Biochemistry,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental
    Nmr
    Lps
    Lipoprotein
    Diabetes
    Cardiovascular risk
    Apoc‐iii
    Apoc-iii
    Saúde coletiva
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry
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