Repositori URV

Autor segons l'article: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; Mas-Llado, Caterina; Li, Linzi; Gonzalez-Casanova, Ines; Salas-Salvado, Jordi; Fito, Montserrat; Alonso, Alvaro

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Salas Salvadó, Jorge

Paraules clau: Volume Validity Stroke Speckle-tracking echocardiography Heart Fibrillation Countries Atrial structure and function Atrial fibrillation Alcohol consumption

Resum: Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.Methods and Results We studied 503 participants from the PREDIMED-Plus (Prevencion con Dieta Mediterranea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).Conclusions In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.Registration URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.

Àrees temàtiques: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: jordi.salas@urv.cat

Identificador de l'autor: 0000-0003-2700-7459

Data d'alta del registre: 2024-08-03

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Journal Of The American Heart Association. 13 (7): e031915-

Referència de l'ítem segons les normes APA: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-. DOI: 10.1161/JAHA.123.031915

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2024

Tipus de publicació: Journal Publications